Trial reportJournal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]2025
Cyanoacrylate Adhesive in Free Gingival Graft Healing: A Digital and Microcirculatory Randomized Clinical Trial.
Trial report in Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.], 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- The effects of cyanoacrylate and concentrated growth factor on wound healing and patient comfort at the palatal donor site: a randomized controlled clinical trial.Clinical oral investigations · 2026Trial
- The Effect of injectable platelet-rich fibrin and low-level laser therapy on graft shrinkage in free gingival grafts: a randomized controlled clinical trial.BMC oral health · 2026Trial
- Cyanoacrylate Adhesive in Free Gingival Graft Healing: A Digital and Microcirculatory Randomized Clinical Trial.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2025Trial
- Two-Step Palatal Shield Technique Using Flowable Composite Resin for Donor-Site Protection Following De-Epithelialized Free Gingival Grafting: A Case Report Illustrating a Novel Technique.Case reports in dentistry · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study aimed to evaluate the efficacy of n-butyl cyanoacrylate (CA) in stabilizing free gingival grafts (FGGs) without sutures at the recipient site and accelerating postoperative healing at the donor site. Additionally, perfusion dynamics and graft shrinkage were assessed using laser Doppler flowmetry (LDF) and digital impression techniques.
methodsThis randomized controlled clinical trial included 40 systemically healthy, non-smoking patients with insufficient keratinized tissue in the mandibular region. Patients were randomly assigned to the test group (FGG stabilized with CA) or the control group (FGG secured with sutures). Periodontal parameters, intraoperative durations, LDF values at recipient and donor sites, graft shrinkage (digital impression), and postoperative pain (VAS scores) were recorded.
resultsGraft shrinkage was significantly lower in the CA group (37.23%) than in the control group (45.15%) (p < 0.001). The test group exhibited significantly higher LDF values at the donor site on days 4 and 7, suggesting enhanced perfusion and early vascularization (p = 0.002, p < 0.001). Postoperative pain (VAS scores) was significantly lower in the CA group until day 6 (p < 0.05). Furthermore, FGG stabilization time was three times shorter in the CA group than in the control group (p < 0.001). By day 30, perfusion values equalized between groups, indicating that CA did not negatively impact long-term tissue healing.
conclusionN-butyl cyanoacrylate provides a rapid, reliable, and minimally traumatic alternative to sutures for FGG stabilization. Its use may reduce graft shrinkage, enhance early vascularization, minimize postoperative pain, and shorten surgical time. These findings support CA as a promising wound dressing and stabilizer in periodontal plastic surgery. However, further randomized clinical trials with larger sample sizes are needed to evaluate its long-term effects.
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