ReviewBiology of reproduction2025
Progress of sex control techniques in mammals†.
Review in Biology of reproduction, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
Abstract
Sex control techniques enable the production of offspring of a specific sex in animals. Methods for achieving sex control in mammals generally fall into two categories: (1) spermatozoa processing pre-fertilization and (2) early embryo sexing after fertilization. This paper reviews and compares spermatozoa processing pre-fertilization based on the physical and chemical characteristics of X and Y spermatozoa, including various sperm separation methods. Early embryo sexing techniques after fertilization are classified into invasive and non-invasive methods. These include karyotyping, polymerase chain reaction based on Y chromosome-specific genes, loop-mediated isothermal amplification based on the specific sequence of Y chromosome, fluorescence in situ hybridization based on a Y-chromosome-specific DNA probe, H-Y antigen detection, X-linked enzyme detection, metabolomics based on the spent culture medium of the embryo, and non-invasive genetic reporter labeling of sex chromosomes. The use of ligands to activate the TLR7/8 signaling pathway in the immunological separation is also reviewed as a potential method for sperm separation. Overall, novel molecular and cell biology methods are enabling the development of sex control technologies, which can positively impact animal production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.