Evidence map›Paper›PMID 40621915›Full record

ArticleMicrobiology spectrum2025

A novel insight into ComE-mediated activation of gene expression in

Hemendra Pal Singh Dhaked, Saswati Biswas, Indranil Biswas

Abstract read
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hemendra Pal Singh DhakedDepartment of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Saswati BiswasDepartment of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID 0000-0002-5571-2895
Indranil BiswasDepartment of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID 0000-0002-9437-1974

Funding

Role of translational fidelity in cellular physiology of oral streptococciR01DE031455 · NIDCR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Indranil Biswas · 2022 to 2026
$2.1M
Exploring the function of novel arginine phosphorylation in streptococcal physiologyR21DE033883 · NIDCR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BISWAS, INDRANIL · 2024 to 2025
$426k
NIDCR NIH HHS DE031455NIDCR NIH HHS DE033883NIDCR NIH HHS R01 DE031455NIDCR NIH HHS R21 DE033883
6 · The paper itself

Abstract

Bacteria use two-component signal transduction systems (TCSs) to sense and respond to environmental changes. TCSs comprise a histidine kinase that senses environmental signals and a response regulator that regulates cognate promoters. Most response regulators are incapable of regulating their promoters in the absence of the cognate histidine kinases. Here, we demonstrated that constitutive expression of the well-studied response regulator ComE of

Indexed as

Bacterial ProteinsGene Expression Regulation, BacterialStreptococcus mutansBacteriocinsHistidine KinasePhosphorylationPromoter Regions, GeneticSignal TransductionBacterial ProteinsBacteriocinsHistidine KinasebacteriocinsComD/ComEoral streptococciStreptococcus mutanstwo-component regulatory systems

Identifiers

PMID40621915
PMCPMC12323615

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.