Evidence map›Paper›PMID 40621905›Full record

ArticlemSystems2025

Inflammation-like environments limit the loss of quorum sensing in

Taoran Fu, Rosanna C T Wright, Danna R Gifford, Christopher G Knight, Michael A Brockhurst

Abstract read
In one paragraph

Article in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Taoran FuDivision of Evolution, Infection and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, England, United Kingdom.ORCID 0000-0003-4683-2171
Rosanna C T WrightDivision of Evolution, Infection and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, England, United Kingdom.
Danna R GiffordDivision of Evolution, Infection and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, England, United Kingdom.
Christopher G KnightDepartment of Earth and Environmental Sciences, School of Natural Sciences, Faculty of Science and Engineering, The University of Manchester, Manchester, England, United Kingdom.ORCID 0000-0001-9815-4267
Michael A BrockhurstDivision of Evolution, Infection and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, England, United Kingdom.ORCID 0000-0003-0362-820X

Funding

Wellcome Trust 220243
6 · The paper itself

Abstract

Within-host environments are complex and multidimensional, making it challenging to link the evolutionary responses of colonizing pathogens to causal selective drivers. Loss of quorum sensing (QS) via mutation of the master regulator, IMPORTANCE:

Indexed as

InflammationPseudomonas aeruginosaPseudomonas InfectionsQuorum SensingBacterial ProteinsGene Expression Regulation, BacterialMutationOxidative StressTrans-ActivatorsBacterial ProteinsLasR protein, Pseudomonas aeruginosaTrans-Activatorschronic infectioncystic fibrosisexperimental evolutionpathogen evolutionPseudomonas aeruginosaquorum sensing

Identifiers

PMID40621905
PMCPMC12363187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.