Evidence map›Paper›PMID 40621863›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Neuroinflammation and amyloid load in different age groups of individuals with Down syndrome: A PET imaging study.

Dimitri B A Mantovani, Laura C Oliveira, Lidia E W Spelta, Claudia L Carvalho, Orestes V Forlenza, Suely K N Marie, Carlos A Buchpiguel, Artur M Coutinho, Daniele de Paula Faria

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dimitri B A MantovaniGraduate Program in Radiology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Laura C OliveiraLaboratory of Nuclear Medicine (LIM-43), Department of Radiology and Oncology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Lidia E W SpeltaLaboratory of Nuclear Medicine (LIM-43), Department of Radiology and Oncology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Claudia L CarvalhoLaboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Orestes V ForlenzaLaboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Suely K N MarieGraduate Program in Neurology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Carlos A BuchpiguelGraduate Program in Radiology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Artur M CoutinhoGraduate Program in Radiology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Daniele de Paula FariaGraduate Program in Radiology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.ORCID 0000-0002-1766-2786

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPq302527/2022-2Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/11728-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/06370-3Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/14294-0Fundação de Amparo à Pesquisa do Estado de São Paulo FAPESP 2018/15167-1the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
6 · The paper itself

Abstract

introductionDown syndrome (DS) is associated with early-onset Alzheimer's disease (AD). This study evaluated neuroinflammation and amyloid beta (Aβ) load in individuals with DS of different ages, using positron emission tomography (PET) imaging.

methodsDS (n = 29) and age-matched non-DS (n = 35) individuals underwent [

resultsIndividuals with DS exhibited increased [ DISCUSSION: Neuroinflammation in DS follows a region-specific pattern, partially associated with amyloid deposition, and may contribute to the early progression of AD-related pathology. HIGHLIGHTS: Neuroinflammation is elevated in Down syndrome (DS) versus age-matched non-DS controls. Neuroinflammation in DS shows a different pattern depending on the brain region. [

Indexed as

Amyloid beta-PeptidesBrainDown SyndromeNeuroinflammatory DiseasesPositron-Emission TomographyAdultAge FactorsAlzheimer DiseaseFemaleHumansMaleMiddle AgedYoung AdultAmyloid beta-Peptides[11C]PK11195Alzheimer's diseaseamyloidDown syndromeneuroinflammationpositron emission tomography

Identifiers

PMID40621863
PMCPMC12230865

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.