Evidence map›Paper›PMID 40621834›Full record

SynthesisTechnology and health care : official journal of the European Society for Engineering and Medicine2025

Polycystic ovary syndrome in women is associated with longer anogenital distance, a new potential biomaker for PCOS.

Shumin Chen, Qiulin Cui, Yue Wu, Weiwen Fan

Expression of concernAbstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Technology and health care : official journal of the European Society for Engineering and Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Shumin ChenDepartment of Obstetrics and Gynecology, Sun Yat-sen University, Zhenyuan Road No.628, Shenzhen 518107, Guangdong, China.
Qiulin CuiDepartment of Obstetrics and Gynecology, Sichuan Provincial Maternity and Child Health Care Hospital, Sichuan 610041, Chengdu, China.
Yue WuDepartment of Obstetrics and Gynecology, Sun Yat-sen University, Zhenyuan Road No.628, Shenzhen 518107, Guangdong, China.
Weiwen FanDepartment of Obstetrics and Gynecology, Sun Yat-sen University, Zhenyuan Road No.628, Shenzhen 518107, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundFetal androgen exposure plays a pivotal role in Polycystic ovary syndrome (PCOS) development and may result in elevated Anogenital distance (AGD). This meta-analysis aimed to investigate the clinical link between PCOS and AGD.MethodsA literature search was performed across various databases to identify studies evaluating AGD in adults with PCOS and without, regardless of language, up to December 2024. The quality of the studies was evaluated using the Newcastle-Ottawa Scale (NOS) scoring system. Random-effects models were utilized to determine mean differences (MDs) and 95% confidence intervals (CIs) in cases of high heterogeneity. This meta-analysis encompassed 4 studies involving a total of 837 participants.ResultsThe pooled analysis found a noteworthy increase of the AGD-ac and AGD-af in PCOS patient compared with the control groups, with an overall MD of AGD-ac = 5.23, 95% CI (2.60, 7.85), P-value < 0.0001, I

Indexed as

Anal CanalGenitalia, FemalePolycystic Ovary SyndromeAdultFemaleHumansandrogensAnogenital distancepolycystic ovary syndromeprenatal exposures

Identifiers

PMID40621834

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.