ArticlePsychological medicine2025
Early predictors of late childhood behavioural outcomes following very preterm birth.
Article in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Mental health outcomes in young adolescents born preterm reveal the need for earlier screening.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Early motor trajectories and distinct psychopathological profiles in adolescents born very and extremely preterm.Frontiers in child and adolescent psychiatry · 2026Article
- Preterm Infants Without Neurological Damage and Nursery Care: Risks, Benefits and Prospects for Intervention.Children (Basel, Switzerland) · 2025Article
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Authors and funding
11 authors.
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Abstract
backgroundChildren born very preterm (VPT; ≤32 weeks' gestation) are at higher risk of developing behavioural problems, encompassing socio-emotional processing and attention, compared to term-born children. This study aimed to examine multi-dimensional predictors of late childhood behavioural and psychiatric outcomes in very preterm children, using longitudinal clinical, environmental, and cognitive measures.
methodsParticipants were 153 VPT children previously enrolled in the Evaluation of Preterm Imaging study who underwent neuropsychological assessments at 18-24 months, 4-7 years and 8-11 years as part of the Brain Immunity and Psychopathology following very Preterm birth (BIPP) study. Predictors of late childhood behavioural and psychiatric outcomes were investigated, including clinical, environmental, cognitive, and behavioural measures in toddlerhood and early childhood. Parallel analysis and exploratory factor analysis were conducted to define outcome variables. A prediction model using elastic-net regularisation and repeated nested cross-validation was applied to evaluate the predictive strength of these variables.
resultsFactor analysis revealed two key outcome factors in late childhood: externalising and internalising-socio-emotional problems. The strongest predictors of externalising problems were response inhibition, effortful control and internalising symptoms in early childhood (cross-validated
conclusionsEarly childhood cognitive and behavioural outcomes predicted late childhood behavioural and psychiatric outcomes in very preterm children. These findings underscore the importance of early interventions targeting cognitive development and behavioural regulation to mitigate long-term psychiatric risks in very preterm children.
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