ArticleBrain and behavior2025
Antidepressant-Like Effects of Electroacupuncture by Regulating NLRP3-mediated Hippocampal Inflammation and Pyroptosis in Rats With Post-Stroke Depression.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of electroacupuncture for post-stroke depression: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Electroacupuncture Stimulation of the Head Motor Area Alleviates Brain Cell Pyroptosis and Neurobehaviors in Stroke Rats Through the NF-κB/NLRP3 Signaling Axis.Neurochemical research · 2026Article
- Dual modulation of the NLRP3/CASPASE-1 inflammasome pathway and gut microbial metabolism: the antidepressant mechanism of puerarin.Frontiers in microbiology · 2026Article
- Central Neurobiological Mechanisms of Acupuncture in Post-Stroke Depression: Multi-Target and Network-Based Regulation.Neuropsychiatric disease and treatment · 2026Review
- Targeting glial cell pyroptosis and neuroinflammation in post-stroke depression: from molecular mechanisms to therapeutic strategies.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveThis study aimed to investigate whether the antidepressant-like effects of electroacupuncture (EA) are associated with the regulation of inflammation and pyroptosis mediated by the NLRP3 inflammasome, as well as the protection of neuron cells in the hippocampus (HP) in a rat model of post-stroke depression (PSD).
methodsDepressive-like behaviors (DLBs) in PSD rats were evaluated through a series of behavioral tests. The expression levels of NLRP3, caspase-1 (Casp-1), and apoptosis-associated speck-like protein (ASC), as well as the cleavage product gasdermin D (GSDMD), were assessed using real-time PCR (RT-PCR), immunofluorescence, and Western blot (WB). IL-1β and IL-18 levels were measured by RT-PCR and WB. To upregulate NLRP3 expression, adeno-associated virus (AAV) was injected into the hippocampus. Nissl staining was employed to evaluate neuronal morphology and count in the hippocampus.
resultsEA significantly alleviated DLBs in PSD rats and suppressed the overexpression of NLRP3, Casp-1, ASC, GSDMD, IL-1β, and IL-18 in the ischemic hippocampus. NLRP3 overexpression attenuated the therapeutic effects of EA on both behavioral outcomes and neuroinflammatory markers.
conclusionsEA mitigated hippocampal inflammation and pyroptosis in PSD by downregulating NLRP3 inflammasome activation, indicating that NLRP3 may serve as a potential therapeutic target for PSD.
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