ArticleBrain and behavior2025
Integrating Genetic and Single-Cell Genomic Data to Reveal Brain Cell-Specific Regulation of Attention-Deficit/Hyperactivity Disorder Risk in the Prefrontal Cortex.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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5 authors.
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Abstract
introductionThe risk of attention-deficit/hyperactivity disorder (ADHD) may involve genetic regulation by specific brain cells in the prefrontal cortex, but the causal associations are currently unclear.
methodsWe integrated single-cell cis-expression quantitative trait loci (cis-eQTLs) from the prefrontal cortex with ADHD genome-wide association studies (GWASs). Using Mendelian randomization (MR) and Bayesian colocalization analyses, we assessed how brain cell-specific gene expression regulation affects ADHD susceptibility. We also examined the association between brain cell-type proportion and ADHD risk and used bioinformatics analyses to explore risk gene functions and identify potential drug-repurposing targets.
resultsSingle-cell eQTL MR analysis revealed that brain cell-specific gene regulation was causally linked to ADHD risk. For example, astrocyte-specific VIM expression was significantly associated with increased ADHD risk (β = 0.167, SE = 0.0388, p = 1.63 × 10
conclusionOur results identify 24 cell-specific genes in the prefrontal cortex that may mediate ADHD risk and highlight promising molecular targets for therapeutic development.
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