SynthesisBrain and behavior2025
A Meta-Analysis of the Association Between Early Venous Filling and Hemorrhagic Transformation After Endovascular Treatment in Acute Large Vessel Occlusion.
Synthesis in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
objectiveThis meta-analysis assessed the link between early venous filling (EVF) and hemorrhagic transformation (HT) post-endovascular treatment (EVT) in acute ischemic stroke (AIS) patients with large vessel occlusion (LVO). MATERIALS AND
methodsWe searched PubMed, Embase, and Cochrane Library. Two reviewers independently screened studies, extracted data, and selected articles per preset criteria. The quality of included studies was assessed by the Newcastle-Ottawa Scale, and RevMan 5 was used for meta-analysis. Stata 15 was used to test for publication bias.
resultsEight studies with 1758 AIS patients were included. EVF was associated with a higher HT rate after EVT (OR 4.5, 95% CI 3.47-5.85, p < 0.001). Subgroup analyses showed EVF was linked to higher incidences of hemorrhagic infarction (HI; OR 1.66, 95% CI 1.03-2.67, p = 0.04), parenchymal hematoma (PH; OR 3.86, 95% CI 2.55-5.83, p < 0.001), and symptomatic intracerebral hemorrhage (sICH; OR 5.95, 95% CI 2.99-11.83, p < 0.001). EVF was also related to a higher 90-day poor prognosis rate (OR 3.12, 95% CI 2.14-4.54, p < 0.001).
conclusionThis meta-analysis shows EVF positively correlates with HT and poor prognosis after EVT, having significant implications for acute LVO stroke management.
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