Article3 Biotech2025
Effects of a green method olive leaf extract on the metabolic disorders and the pancreatic immunohistopathology in diabetic Wistar rats.
Article in 3 Biotech, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study evaluated the antidiabetic potential of a green, oleuropein-rich extract from olive leaves in alloxan-induced diabetic Wistar rats. Diabetes was induced by a single intraperitoneal injection of alloxan (180 mg/kg b.w.), followed by oral administration of the extract for 30 days. Treatment significantly decreased blood glucose levels from 26 mmol/L in diabetic controls to 5 mmol/L and increased plasma insulin concentrations from 4.65 µU/mL to 13.25 µU/mL. Improvements in body weight, antioxidant defense, and lipid and liver enzyme profiles were also recorded. Histological examination revealed structural restoration of pancreatic tissue, while immunohistochemical analysis indicated enhanced expression of the anti-apoptotic protein Bcl-2, suggesting a protective and regenerative effect on pancreatic β-cells. The solvent-free extraction method preserved the bioactivity of the compound and supports its safe use for therapeutic purposes. Collectively, these findings highlight the efficacy of the oleuropein-rich extract in restoring glycemic balance and pancreatic function, suggesting its promise as a natural and sustainable option for diabetes management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.