ArticlePakistan journal of medical sciences2025
Efficacy of donepezil combined with rehabilitation training in the treatment of Alzheimer's disease.
Article in Pakistan journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Objective: To examine the efficacy of donepezil combined with rehabilitation training for treating Alzheimer's disease (AD) and its impact on nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). Methods: This single center retrospective analysis was conducted at the First Affiliated Hospital of Chongqing Medical and Pharmaceutical College and included 184 patients with AD treated between January 2022 to May 2024. Of them, 92 patients who received donepezil combined with rehabilitation training (combined group) were matched in a 1:1 ratio with a cohort that received donepezil alone (donepezil group). The treatment efficacy, cognitive function, ability to engage in daily living activity before and after the treatment, serum NGF and BDNF levels, and incidence of adverse reactions were compared between the two groups. Results: The total efficacy of patients in the combined group was higher than that of the donepezil group ( Conclusions: Compared with donepezil alone, the combination of donepezil and rehabilitation training is associated with significantly improved therapeutic effects and better serum NGF and BDNF levels.
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