ReviewFrontiers in immunology2025
The role of notch signaling pathway and non-coding RNAs in cancer and inflammation: progress, therapeutic insights, and future directions.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Review
- Notch2, a Key Player in Chronic Lymphocytic Leukemia: Mechanism, Microenvironment Interactions, and Therapeutic Implications.Cancers · 2026Review
- Notch signaling in the tumor microenvironment: recent advances and targeted therapeutics.Molecular cancer · 2026Review
- Subtype-Independent Dysregulation of the Notch Signaling Pathway and Its miRNA Regulators in Breast Cancer.Biomedicines · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Notch signaling pathway and non-coding RNAs (ncRNAs) play significant roles in regulating key cellular processes such as cancer progression, metastasis, and drug resistance. This article systematically reviews the interactions between the Notch pathway and ncRNAs including miRNAs, lncRNAs, and circRNAs, as well as their overall impact on cancer biology. We focus on the latest research progress on how ncRNAs regulate the Notch pathway through transcriptional regulation, post-transcriptional modifications, and epigenetic mechanisms, and discuss how such interactions affect tumor microenvironment shaping, immune escape mechanisms, and treatment sensitivity. Additionally, this article deeply analyzes potential therapeutic strategies targeting the Notch-ncRNA axis, including its prospects for synergistic application with chemotherapy, radiotherapy, and immunotherapy. By integrating multi-cancer experimental data, we propose individualized diagnosis and treatment strategies based on tumor-specific Notch pathway and ncRNA expression patterns.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.