Evidence map›Paper›PMID 40621469›Full record

ArticleFrontiers in immunology2025

Dietary inflammation: a potential driver of atopic dermatitis?-Evidence from KNHANES 2017-2023.

Kaiyue Tan, Nanren Sun, Dongyang Wang, Jiaojiao Chen, Jiaqi Long, Junbin Zhang

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Kaiyue Tan *The First Clinical College of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Nanren Sun *The First Clinical College of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Dongyang WangDepartment of Dermatology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Jiaojiao ChenThe First Clinical College of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Jiaqi LongThe First Clinical College of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Junbin ZhangDepartment of Dermatology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The global incidence of atopic dermatitis (AD) has risen significantly in recent decades, with trends showing spatial and temporal coupling with dramatic changes in dietary habits during industrialisation. Although the Dietary Inflammatory Index (DII), a tool to quantify the inflammatory potential of diet, has made breakthroughs in the study of chronic inflammatory diseases, large-scale cross-sectional evidence for its association with AD is still lacking. Methods: Based on large-scale population-based cross-sectional data from Korean National Health and Nutrition Examination Survey(KNHANES)2017-2023, the association between DII quartiles and AD risk was analysed using weighted multivariate logistic regression, with adjusted odds ratios (aORs) and 95% CIs calculated, stratified by sex (male/female) and age (≤54 vs >54); interactions were assessed by the Wald test, and the association between dietary index and risk was assessed using the Restricted cubic spline(RCS) models (with nodes set at the 10th, 50th, and 90th percentiles of DII) were used to explore non-linear associations, with models adjusted for covariates such as sex, age, and education. Results: Higher DII scores showed a significant association with AD prevalence. Participants in the highest DII quartile had a 73% higher risk than those in the lowest quartile (aOR = 1.73, 95% CI = 1.45-2.07).and the sex interaction was significant (interaction p<0.05), with stronger associations in the female group; RCS analyses showed a possible linear association between DII and AD risk (non-linear p>0.05). Conclusion: High dietary inflammatory index was significantly and positively associated with high prevalence of AD, especially in female and younger age groups; Notably, higher intake of dietary fiber and carotene is associated with a lower prevalence of AD.

Indexed as

Dermatitis, AtopicDietInflammationAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedNutrition SurveysPrevalenceRepublic of KoreaRisk FactorsYoung Adultage stratificationatopic dermatitisDietary Inflammation Indexdietary patternsKNHANESrestricted cubic spline modelssex stratification

Identifiers

PMID40621469
PMCPMC12226286

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