Evidence map›Paper›PMID 40621462›Full record

ArticleFrontiers in immunology2025

Comparison of homologous and heterologous vaccination strategies for combating disease caused by

Sergei S Biryukov, Christopher K Cote, Christopher P Klimko, Jennifer L Dankmeyer, Nathaniel O Rill, Melissa Hunter, Michael L Davies, Zander M Hedrick, Jennifer L Shoe, Lindsey K Schmidt and 6 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Sergei S Biryukov *United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Bacteriology Division, Frederick, MD, United States.
Christopher K Cote *United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Bacteriology Division, Frederick, MD, United States.
Christopher P KlimkoUnited States Army Medical Research Institute of Infectious Diseases (USAMRIID), Bacteriology Division, Frederick, MD, United States.
Jennifer L DankmeyerUnited States Army Medical Research Institute of Infectious Diseases (USAMRIID), Bacteriology Division, Frederick, MD, United States.
Nathaniel O RillUnited States Army Medical Research Institute of Infectious Diseases (USAMRIID), Bacteriology Division, Frederick, MD, United States.
Melissa HunterUnited States Army Medical Research Institute of Infectious Diseases (USAMRIID), Bacteriology Division, Frederick, MD, United States.
Michael L DaviesUnited States Army Medical Research Institute of Infectious Diseases (USAMRIID), Bacteriology Division, Frederick, MD, United States.
Zander M HedrickUnited States Army Medical Research Institute of Infectious Diseases (USAMRIID), Bacteriology Division, Frederick, MD, United States.
Jennifer L ShoeUnited States Army Medical Research Institute of Infectious Diseases (USAMRIID), Bacteriology Division, Frederick, MD, United States.
Lindsey K SchmidtDepartment of Microbiology and Immunology, University of Nevada, Reno School of Medicine, Reno, NV, United States.
Caitlyn E OrneDepartment of Microbiology and Immunology, University of Nevada, Reno School of Medicine, Reno, NV, United States.
Ju QiuUnited States Army Medical Research Institute of Infectious Diseases (USAMRIID), Biostatistics Division, Frederick, MD, United States.
Susan L WelkosUnited States Army Medical Research Institute of Infectious Diseases (USAMRIID), Bacteriology Division, Frederick, MD, United States.
Mary N BurtnickDepartment of Microbiology and Immunology, University of Nevada, Reno School of Medicine, Reno, NV, United States.
Paul J BrettDepartment of Microbiology and Immunology, University of Nevada, Reno School of Medicine, Reno, NV, United States.
David DeShazerUnited States Army Medical Research Institute of Infectious Diseases (USAMRIID), Bacteriology Division, Frederick, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Melioidosis is a major cause of disease and mortality in endemic tropical regions, and the etiologic agent, Methods: In the current study, we evaluated homologous and heterologous combinations of candidate subunits and live vaccines in a murine aerosol model of melioidosis to determine the effects of vaccine composition and delivery scheme on protection in conjunction with immune responses and bacterial clearance. Results: Both strategies provided significant protection against lethal aerosol challenges, and the accumulated data support that a heterologous vaccination strategy employing capsular polysaccharide conjugate and Hcp1 subunits and a live but highly safe capsular polysaccharide-producing surrogate strain of

Indexed as

Bacterial VaccinesBurkholderia pseudomalleiMelioidosisVaccinationAnimalsAntibodies, BacterialAntigens, BacterialDisease Models, AnimalFemaleHumansMiceMice, Inbred BALB CVaccines, AttenuatedAntibodies, BacterialAntigens, BacterialBacterial VaccinesVaccines, AttenuatedBurkholderia pseudomalleiheterologousimmunitymelioidosismiceprotectionvaccines

Identifiers

PMID40621462
PMCPMC12226310

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.