Evidence map›Paper›PMID 40621429›Full record

ArticleClinical ophthalmology (Auckland, N.Z.)2025

Intraocular Pressure Control in Vitreoretinal Surgical Systems.

Martin Charles, Ying Zhu, Carrie Garufis, Brian McDonell, Varalakshmi D Wuyyuru

Abstract read
In one paragraph

Article in Clinical ophthalmology (Auckland, N.Z.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Martin CharlesCharles Centro Oftalmológico, Buenos Aires, Argentina.
Ying ZhuAlcon Research LLC, Lake Forest, CA, USA.
Carrie GarufisAlcon Research LLC, Lake Forest, CA, USA.
Brian McDonellAlcon Research LLC, Lake Forest, CA, USA.
Varalakshmi D WuyyuruAlcon Research LLC, Lake Forest, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: A comparison was made between the Constellation Patients and Methods: An acrylic eye model was connected to a vitrectomy probe, an infusion cannula, and a pressure transducer. The Constellation and EVA systems were tested using 25-gauge probes in vacuum mode with vacuum settings at 250, 450, and 650 mmHg. The target IOP was 30 mmHg. Average IOP was assessed before aspiration (initial IOP), during vitreous removal (vitreous IOP), and after vitreous removal and replacement with Alcon's BSS Results: Using Constellation's IOP control, target IOP (30±2.5 mmHg) was maintained 93%, 74%, and 63% of the time at 250, 450, and 650 mmHg of vacuum, respectively. At 650 mmHg, initial IOP, vitreous IOP, and BSS IOP were 30.18±0.18, 30.99±0.66, and 31.55±1.38 mmHg. Using EVA with AIC, target IOP was maintained 16%, 17%, and 23% of the time at 250, 450, and 650 mmHg of vacuum. At 650 mmHg, initial IOP, vitreous IOP, and BSS IOPs were 30.54±0.08, 44.62±1.24, and 29.92±0.72 mmHg (P<0.0001). Conclusion: When confronted with dynamic fluid conditions during vitreous removal, the Constellation system with IOP control automatically maintained stable IOP in the target range 63% to 93% of the time at different vacuum settings versus ≤23% of the time with the EVA system with AIC.

Indexed as

automatic infusion compensation(AIC)constellationDORC EVAIOP controlvitrectomy

Identifiers

PMID40621429
PMCPMC12226710

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.