ArticleCureus2025
Oncocytic Features in Choroid Plexus Tumors: An Integrative Clinicopathological Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChoroid plexus tumors (CPTs) are rare epithelial brain tumors. Recent studies have found changes in the cells and the presence of amyloid, but these tiny details are still not well understood. Limited information is available regarding the biology of oncocytic changes (OCs) in CPTs. MATERIAL AND
methodsThis study included 42 primary and recurrent CPTs. Out of these, 28 cases (67%) were grade I choroid plexus papilloma (CPP), eight cases (19%) were grade II atypical choroid plexus papilloma (ACPP), and six cases (14%) were grade III choroid plexus carcinomas (CPCs), based on the World Health Organization (WHO) 2021 classification.
resultsWe observed OCs in 10 (36%) CPP cases, three (38%) ACPP cases, and one (17%) CPC case (p = 0.643). We correlated these changes with mortality (p = 0.049), necrosis (p = 0.014), hemorrhage (p = 0.000), amyloid deposition, psammoma bodies, and brain invasion. OCs showed a positive reaction to fascin, CD1a, interleukin (IL)-2, IL-6, tumor necrosis factor-alpha (TNF-α), CD68, and hypoxia-inducible factor 1-alpha (HIF-1α), but the epithelial cells in CPP and CPC did not react. The detailed examination showed both normal and unusual mitochondria, fat droplets, thread-like materials, microtubules, amyloid buildup, and problems with cilia.
conclusionOCs in CPTs are rare and likely associated with inflammatory, ischemic, and hypoxic conditions. These changes might show dendritic cells (DCs) that help protect the blood-brain barrier, monitor the immune system, or support aging cells that promote flexibility and healing in tissues. Furthermore, we linked them to ciliary dysfunction. We need further studies to better understand this rare phenomenon in CPTs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.