ArticleCureus2025
A "Time-Kill" Study to Assess the Effect of Colistin on Gram-Negative Strains: An Experimental Study for Developing an Indigenous Microfluidics-Based Antimicrobial Susceptibility Testing Device.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
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Abstract
The emergence of infections caused by multidrug-resistant gram-negative strains has necessitated the reuse of polymyxins, which are repurposed antimicrobials due to their initial toxicity profile. However, the present antimicrobial susceptibility testing (AST) methods against them are challenging to perform or need validation. Through this study, we sought to determine how early we can differentiate between the susceptible and resistant gram-negative strains when exposed to a single breakpoint concentration of antibiotic, as expected from a microfluidics-based AST. We used time-kill assay and cell-viability assay to image the organisms and draw a parallel to the principle of microfluidics-based assay. Reference and clinical strains of Enterobacterales and
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