Evidence map›Paper›PMID 40621331›Full record

ReviewCureus2025

Sepsis-induced Atrial Fibrillation: Can We Predict and Prevent This High-Risk Complication?

Vahagn Tamazyan, Aleksan Khachatryan, Ashot Batikyan, Hakob Harutyunyan, Binit Aryal, Supraja Achuthanandan, Gerald Hollander

Abstract readReview
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vahagn TamazyanDepartment of Internal Medicine, Maimonides Medical Center, Brooklyn, USA.
Aleksan KhachatryanDepartment of Cardiovascular Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, New York, USA.
Ashot BatikyanDepartment of Internal Medicine, Albert Einstein College of Medicine, Jacobi Medical Center, North Central Bronx Hospital, New York, USA.
Hakob HarutyunyanDepartment of Internal Medicine, Maimonides Medical Center, Brooklyn, USA.
Binit AryalDepartment of Cardiology, Maimonides Medical Center, Brooklyn, USA.
Supraja AchuthanandanDepartment of Cardiology, Maimonides Medical Center, Brooklyn, USA.
Gerald HollanderDepartment of Cardiology, Maimonides Medical Center, Brooklyn, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis-induced new-onset atrial fibrillation (NOAF) is a frequent and serious complication in critically ill patients, linked to increased morbidity, mortality, stroke, and prolonged hospitalization. Though often transient during acute illness, NOAF is now recognized as a predictor of long-term cardiovascular vulnerability, with recurrence rates exceeding 50% over five years and a significantly heightened risk of thromboembolic events. Stroke risk is notably elevated in this population, yet the role of anticoagulation remains uncertain due to potential bleeding complications and lack of clear guidelines. This review consolidates current evidence on the pathophysiology, incidence, risk factors, and clinical impact of sepsis-induced NOAF, with a focus on stroke prevention, recurrence, anticoagulation challenges, and emerging predictive models. Additionally, it examines prevention strategies that target inflammatory and hemodynamic pathways.

Indexed as

anticoagulationatrial fibrillationcritical illnessinflammationprediction modelspreventionsepsisstroke risk

Identifiers

PMID40621331
PMCPMC12229231

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.