ReviewCureus2025
Cardiometabolic Health Burden in Pediatric HIV: Unmet Need in the Contemporary Antiretroviral Therapy Era.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Risk factors associated with adverse metabolic health in youth with perinatally acquired HIV living in the United Kingdom.AIDS (London, England) · 2026Observational
- The Long Shadow of Early HCMV-HIV Coinfection: Epidemiology, Pathogenesis, and Immune Consequences.Children (Basel, Switzerland) · 2026Review
- Knowledge, attitudes, and practices in cardiometabolic health among adolescents and adults in HIV care in Dar es Salaam, Tanzania.Frontiers in public health · 2026Article
- Long-term lipoprotein and lipid profiles and association with metabolic risk markers in youth with perinatally acquired HIV and matched controls: a 10-year comparative cohort study.Lipids in health and disease · 2025Observational
- Cardiovascular Risk in People Living with HIV: A Preliminary Case Study from Romania.Medicina (Kaunas, Lithuania) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In children and adolescents with perinatally acquired HIV-1, early and prolonged exposure to HIV-1 and antiretroviral therapy (ART) can impact the premature development of cardiometabolic comorbidities. This narrative literature review aims to provide an overview of the impact of contemporary ART regimens on lipid profiles, body composition, and cardiovascular health in this population. Additionally, we propose recommendations for addressing cardiometabolic health in this understudied group. Studies show an increased risk of cardiovascular disease, adipose tissue dysfunction, and dyslipidemia among children and adolescents with perinatally acquired HIV-1. Clinical trial data support that contemporary ART regimens show better cardiometabolic profiles compared with older regimens. Emerging data suggest that chronic inflammation, epigenetic changes, gut barrier dysfunction, and oxidative stress are key mechanisms contributing to worsened cardiometabolic health in pediatric populations with HIV-1. People working with children and adolescents with HIV-1 should be aware of the increased risk of cardiometabolic health disorders in this population. More well-designed studies investigating cardiometabolic health in pediatric populations using contemporary ART regimens are needed. Early interventions during childhood and adolescence, critical developmental stages, may yield long-term benefits for health, quality of life, and longevity. A proactive, holistic approach to clinical management involving comprehensive care and early assessments of cardiometabolic health is essential to forestall the development of chronic disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.