ArticleCureus2025
Delayed Diagnosis of Sheehan's Syndrome in an 89-Year-Old Female: A Case Report and Review of Literature.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Sheehan's syndrome, a rare consequence of severe postpartum hemorrhage, is marked by partial or complete deficiencies in pituitary hormones due to pituitary infarction. Patients may not exhibit symptoms for decades, often delaying the pursuit of medical attention. We present the case of an 89-year-old woman who exhibited symptoms of hyponatremia and adrenal insufficiency, with a history of severe postpartum hemorrhage that led to a hysterectomy 46 years ago. Her hormonal panel revealed deficiencies across all anterior pituitary gland axes. MRI findings showed a partially empty sella. To our knowledge, this case has the longest documented delay in presentation, exceeding four decades. It underscores the need to maintain a high clinical suspicion for alternative causes of hypoosmolar hyponatremia, particularly in cases unresponsive to rehydration therapy.
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