ArticleCureus2025
The Expression of Laminin-5 in Malignant Lesions of the Oral Cavity and Its Association With the Aggressiveness of the Tumor.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Oral squamous cell carcinoma (OSCC) constitutes a major subset of head and neck cancers, with significant variability in clinical outcomes. Laminin-5, a key extracellular matrix protein involved in cell adhesion and invasion, may serve as a biomarker for tumor aggressiveness. This cross-sectional study involved 30 histologically confirmed OSCC patients who underwent surgical excision at Safdarjung Hospital, New Delhi. Immunohistochemical staining was used to assess laminin-5 expression, which was then correlated with tumor thickness, differentiation, TNM staging, and metastasis. Laminin-5 positivity was observed in 83.4% of cases. A statistically significant association was found between laminin-5 expression and tumor differentiation (p = 0.027), with the highest mean expression seen in moderately differentiated tumors (65.24%). No significant correlation was noted between laminin-5 expression and tumor stage, nodal status, metastasis, or tumor thickness. These findings suggest that laminin-5 may serve as a useful histological marker of tumor differentiation in OSCC and could aid in evaluating tumor behavior and prognosis.
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