ArticleCureus2025
Vitamin B12 and D3 Levels in Leprosy Patients With or Without Deformity: A Cross-Sectional, Analytic Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConsidering the role of vitamins B12 and D3 in musculoskeletal, bone, and nerve health, their possible role in deformity among leprosy patients remains to be investigated. The study compared vitamin B12 and D3 levels in leprosy patients with and without deformity, aiming to identify the cut-off points that predict deformity and neuritis.
methodsWith approval and informed consent, clinic-demographic, leprosy disease, and deformity-related data, as well as vitamin B12 and D3 levels, were recorded among both new and established leprosy patients attending the outpatient department from mid-February to mid-May 2024 and were categorized based on the presence or absence of deformities for comparison. Areas under the receiver operating characteristic curves (AuROC) and Youden's J point for vitamin B12 and D3 levels, predicting deformity and neuritis, were also evaluated. Statistical significance was set at p < 0.05.
resultsData from 50 participants (21 with deformities) were analyzed. Patients with deformities were less educated compared to those without (p = 0.03). Similarly, the number of homemakers, daily wagers, and farmers was significantly higher in the deformities group. The prevalence of B12 and D3 deficits was 2 (9.52%) and 4 (19.04%) in patients with deformity and three (10.34%) and one (3.45%) in patients without deformity, respectively. Neuritis was more common in the deformity group (42.86% vs. 17.24%); however, the levels of B12 and D3 were statistically equivalent. AuROC (95% confidence) for B12 level and D3 for deformity were 0.405 (0.237-0.573) and 0.599 (0.434-0.764), and for neuritis, 0.645 (0.464-0.826) and 0.508 (0.339-0.677), respectively.
conclusionThe present study showed an insignificant relationship between Vitamin B12 and Vitamin D3 levels in patients with and without deformities. Similar results were observed in neuritis. However, a relationship was found between socioeconomic status and deformity in patients with leprosy. Our interpretation, however, is limited by a single-center, nonlongitudinal design of study with a small sample size and a single testing occasion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.