ArticleFrontiers in oral health2025
Investigating the impact of polymorphisms in the
Article in Frontiers in oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Previous studies have reported that genetic polymorphisms may impact the signs and symptoms of temporomandibular disorder (TMD). Therefore, this study aimed to investigate the association between polymorphisms in the Methods: This cross-sectional study included construction workers with at least one sign or symptom of TMD. The reduced version of the Oral Health Impact Profile questionnaire (OHIP-14) was used to assess oral health-related quality of life. Genomic DNA was used to genotype genetic polymorphisms in the locus 11q22-q23, one in Results: The sample included a total of 114 male patients. OHIP-14 total score ranged from 0 to 33. Chronic pain (87.7%), followed by disc displacement (38.2%), was the most common sign and symptom observed. All the genetic polymorphisms assessed were within the Hardy-Weinberg equilibrium. The "Handicap" domain (D6) was statistically associated with the genetic polymorphism rs1800497 in Discussion: This study showed that genetic polymorphisms can negatively impact the oral health-related quality of life, as measured by the handicap domain of the OHIP-14. The physical and emotional condition of patients, together with biological pathways, should receive more attention in future studies, and personalized treatment plans should be created to improve patients' quality of life.
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