Evidence map›Paper›PMID 40621167›Full record

ArticleJournal of biomedical optics2025

Yinghan Xu, Srikamal Soundararajan, Scott H Randell, Nicusor Iftimia, Gopi Maguluri, John Grimble, Carlton J Zdanski, Amy L Oldenburg

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yinghan XuUniversity of North Carolina at Chapel Hill, Department of Biomedical Engineering, Chapel Hill, North Carolina, United States.
Srikamal SoundararajanUniversity of North Carolina at Chapel Hill, Biomedical Research Imaging Center, Chapel Hill, North Carolina, United States.ORCID 0000-0002-5646-9794
Scott H RandellUniversity of North Carolina at Chapel Hill, Marsico Lung Institute, Chapel Hill, North Carolina, United States.
Nicusor IftimiaPhysical Sciences Inc., Andover, Massachusetts, United States.ORCID 0000-0002-7713-6972
Gopi MaguluriPhysical Sciences Inc., Andover, Massachusetts, United States.
John GrimblePhysical Sciences Inc., Andover, Massachusetts, United States.
Carlton J ZdanskiUniversity of North Carolina at Chapel Hill, Department of Otolaryngology/Head and Neck Surgery, Chapel Hill, North Carolina, United States.
Amy L OldenburgUniversity of North Carolina at Chapel Hill, Department of Biomedical Engineering, Chapel Hill, North Carolina, United States.ORCID 0000-0002-2642-8350

Funding

Predicting the Need for Surgery in Pediatric Subglottic Stenosis using Airway Elastography Derived from Endoscopic OCT and Intraluminal Pressure MeasurementR01HL154429 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI OLDENBURG, AMY L, ZDANSKI, CARLTON J · 2020 to 2024
$4.0M
Endoscopic Multifunctional Optical Coherence Tomography for Airway Tissue Injury ManagementR43HL154866 · NHLBI · PHYSICAL SCIENCES, INC · PI IFTIMIA, NICUSOR · 2020 to 2020
$259k
NHLBI NIH HHS R01 HL154429NHLBI NIH HHS R43 HL154866
6 · The paper itself

Abstract

Significance: Inhalation injury, a critical complication in patients with severe burns, contributes substantially to morbidity and mortality. Current diagnostic practices suffer from subjectivity and lack quantitative metrics. Enhanced diagnostic accuracy is imperative for improving treatment outcomes. Aim: Our objective was to develop normalized cross-sectional compliance (nCsC) of the airway wall, as measured by anatomical optical coherence tomography (aOCT), to reflect the severity of trachea inhalation injury. Approach: We employed a customized aOCT system that incorporates an intraluminal pressure probe to assess nCsC Results: We revealed that airway wall nCsC decreased initially after injury but exhibited recovery at 4 h. This is supported by ANOVA results showing that nCsC was significantly influenced by time ( Conclusions: Airway wall nCsC is a promising quantitative metric for assessing inhalation injury. Future translation of this aOCT-based technology to humans may potentially enhance clinical management of inhalation injuries.

Indexed as

Burns, InhalationElasticity Imaging TechniquesTomography, Optical CoherenceTracheaAnimalsSwineairway complianceinhalation injuryoptical coherence elastography

Identifiers

PMID40621167
PMCPMC12223793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.