Evidence map›Paper›PMID 40620913›Full record

ArticleIn silico pharmacology2025

Lupeol acetate from

James Diokadan, Ishimwe Aimée Divine, Shamasamu Emma, Rutendo Samantha Makiwa, Uwizera Celine, Lucky Nicholus, Ssekikubo Ronald, Sreya Kosanam, Rajeshwari Pasupula

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PubMed Full text at PMC Publisher
In one paragraph

Article in In silico pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

James DiokadanDepartment of Pharmacology, College of Pharmacy, Koneru Lakshmaiah Education Foundation, KL Deemed to Be University, Green Fields, Vaddeswaram, Andhra Pradesh India.
Ishimwe Aimée DivineDepartment of Pharmacology, College of Pharmacy, Koneru Lakshmaiah Education Foundation, KL Deemed to Be University, Green Fields, Vaddeswaram, Andhra Pradesh India.
Shamasamu EmmaDepartment of Pharmacology, College of Pharmacy, Koneru Lakshmaiah Education Foundation, KL Deemed to Be University, Green Fields, Vaddeswaram, Andhra Pradesh India.
Rutendo Samantha MakiwaDepartment of Pharmacology, College of Pharmacy, Koneru Lakshmaiah Education Foundation, KL Deemed to Be University, Green Fields, Vaddeswaram, Andhra Pradesh India.
Uwizera CelineDepartment of Pharmacology, College of Pharmacy, Koneru Lakshmaiah Education Foundation, KL Deemed to Be University, Green Fields, Vaddeswaram, Andhra Pradesh India.
Lucky NicholusDepartment of Pharmacology, College of Pharmacy, Koneru Lakshmaiah Education Foundation, KL Deemed to Be University, Green Fields, Vaddeswaram, Andhra Pradesh India.
Ssekikubo RonaldDepartment of Pharmacology, College of Pharmacy, Koneru Lakshmaiah Education Foundation, KL Deemed to Be University, Green Fields, Vaddeswaram, Andhra Pradesh India.
Sreya KosanamFaculty of Pharmacy, Dr. M.G.R. Educational and Research Institute, Velappanchavadi, Chennai, India.
Rajeshwari PasupulaDepartment of Pharmacology, College of Pharmacy, Koneru Lakshmaiah Education Foundation, KL Deemed to Be University, Green Fields, Vaddeswaram, Andhra Pradesh India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lupeol acetate, a naturally occurring pentacyclic triterpenoid with anti-inflammatory, antioxidant, and cardioprotective properties, was identified from the methanolic extract of Methods: The methanolic extract of Results: Among 32 identified compounds, lupeol acetate exhibited favorable pharmacokinetics, low toxicity, and high drug-likeness. WGCNA revealed JAK2, a key regulator of inflammatory pathways and immune signaling, as a critical hub gene associated with MI-related mechanisms, including apoptosis and inflammation. Molecular docking demonstrated strong binding between lupeol acetate and JAK2, which was confirmed by molecular dynamics simulations showing a stable protein-ligand complex. Conclusion: This study identifies lupeol acetate as a promising cardioprotective candidate. By integrating WGCNA with computational analyses, it provides novel insights into the molecular mechanisms of Supplementary Information: The online version contains supplementary material available at 10.1007/s40203-025-00383-9.

Indexed as

Cleome viscosaJAK2Lupeol acetateMyocardial infarctionPI3K-Akt pathway

Identifiers

PMID40620913
PMCPMC12226438

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.