Evidence map›Paper›PMID 40620902›Full record

ArticleiScience2025

Induction of hemagglutinin stalk reactive antibodies by the administration of a live-attenuated influenza virus vaccine in children.

Juan Manuel Carreño, Philip Meade, Na Fatimata Sogodogo, Kaori Sano, Johnstone Tcheou, Ariel Raskin, Gagandeep Singh, Miriam Fried, Madhumathi Loganathan, Benjamin Francis and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Juan Manuel CarreñoDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Philip MeadeDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Na Fatimata SogodogoDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kaori SanoDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Johnstone TcheouDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ariel RaskinDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gagandeep SinghDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Miriam FriedDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Madhumathi LoganathanDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Benjamin FrancisDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Dominika BielakDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ya Jankey JagneVaccines and Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, The Gambia.
Hadijatou J SalahVaccines and Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, The Gambia.
Florian KrammerDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Thushan I de SilvaVaccines and Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, The Gambia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early life exposures to influenza viruses may imprint a hemagglutinin group-specific signature on immunity that impacts future responses to infection or vaccination. We assessed the administration of a live attenuated influenza virus (LAIV) vaccine in children. Two LAIV formulations (2016-17 and 2017-18) containing distinct H1N1 components were used. Modest boosting of pre-existing serum stalk reactive titers and enhancement of functional antibody-dependent cellular cytotoxicity activity (ADCC) was observed. The magnitude of stalk antibody induction in children naive to influenza A viruses was low; however, LAIV induced

Indexed as

Immunity

Identifiers

PMID40620902
PMCPMC12226393

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.