Evidence map›Paper›PMID 40620853›Full record

ArticleFrontiers in pediatrics2025

Center-specific variation in outcomes for extremely premature, extremely low birth weight neonates.

Sai Manasa Kalyanam, Jordan R Kuiper, Theodore J Iwashyna, Lindsey A Knake, Esther G Lee, James L Wynn, Khyzer B Aziz

Abstract read
In one paragraph

Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sai Manasa KalyanamDepartment of Pediatrics, Johns Hopkins University, Baltimore, MD, United States.
Jordan R KuiperDepartment of Environmental and Occupational Health, George Washington University, Washington, DC, United States.
Theodore J IwashynaDepartment of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, United States.
Lindsey A KnakeDepartment of Pediatrics, University of Iowa, Iowa City, IA, United States.
Esther G LeeDepartment of Pediatrics, Rush University, Chicago, IL, United States.
James L WynnDepartment of Pediatrics, University of Florida, Gainesville, FL, United States.
Khyzer B AzizDepartment of Pediatrics, Johns Hopkins University, Baltimore, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The survival rate of neonates born with extremely low birth weight (<1,000 g) and extremely preterm (<29 gestational age) has significantly improved with advances in neonatal care. Despite such advances, outcomes vary widely across neonatal intensive care units due to differences in care practices and patient population. In this study, we examined 1,627 extremely low birth weight and extremely preterm infants admitted to three NICUs across the United States between 2013 and 2023. We evaluated survival and severe intraventricular hemorrhage (SIVH) using statistical models that were adjusted for maternal and neonatal characteristics. Significant differences in outcomes were observed between the centers. These differences were associated with variations in care practices, including resuscitation decisions for the infants. Despite these differences, all centers achieved survival without SIVH for a substantial number of infants, annually. These findings emphasize the need for evidence-based practice-sharing and improvements to ensure better and more consistent care.

Indexed as

center-specific variationextremely low weightextremely prematureneonatal careneonatal practices

Identifiers

PMID40620853
PMCPMC12226493

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.