Evidence map›Paper›PMID 40620842›Full record

ArticleBurns & trauma2025

Three-dimensional composite aerogel scaffolds based on electrospun poly(lactic acid)/gelatin and silica-strontium oxide short fibers promote bone defect healing.

Jie Cui, Lixiang Zhang, Muhammad Shafiq, Panpan Shang, Xiao Yu, Yangfan Ding, Pengfei Cai, JiaHui Song, Binbin Sun, Mohamed El-Newehy and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Burns & trauma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jie CuiState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, No. 2999 North Renmin Road, Songjiang District, Donghua University, Shanghai 201620, P.R. China.
Lixiang ZhangDepartment of Orthopaedics, Xinqiao Hospital, Army Medical University, No. 183, Xinqiao Street, Shapingba District, Chongqing 400037, P. R. China.
Muhammad ShafiqInnovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, Kawasaki-ku, Kawasaki 210-0821, Japan.
Panpan ShangInstitute of Biomaterials and Biomedicine, School of Food and Pharmacy, Shanghai Zhongqiao Vocational and Technical University, Shanghai 201514, P.R. China.
Xiao YuState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, No. 2999 North Renmin Road, Songjiang District, Donghua University, Shanghai 201620, P.R. China.
Yangfan DingState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, No. 2999 North Renmin Road, Songjiang District, Donghua University, Shanghai 201620, P.R. China.
Pengfei CaiG.E.R.N. Research Center for Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine, Medical Center-Albert-Ludwigs-University of Freiburg, 79085 Freiburg in Breisgau, Germany.
JiaHui SongState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, No. 2999 North Renmin Road, Songjiang District, Donghua University, Shanghai 201620, P.R. China.
Binbin SunState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, No. 2999 North Renmin Road, Songjiang District, Donghua University, Shanghai 201620, P.R. China.
Mohamed El-NewehyDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Meera Moydeen AbdulhameedDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Stachewicz UrszulaAGH University of Krakow, college of Materials, Poland.
Xingping ZhouState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, No. 2999 North Renmin Road, Songjiang District, Donghua University, Shanghai 201620, P.R. China.
Yuan XuDepartment of Orthopaedics, Xinqiao Hospital, Army Medical University, No. 183, Xinqiao Street, Shapingba District, Chongqing 400037, P. R. China.
Xiumei MoState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, No. 2999 North Renmin Road, Songjiang District, Donghua University, Shanghai 201620, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Bone defect regeneration is a dynamic healing process that relies on the body's innate repair mechanisms, yet natural healing capacity remains limited. To address this challenge, advanced biomaterials combining bioactive inorganic components with biocompatible polymers have emerged as a promising strategy to enhance osteogenesis and angiogenesis. Methods: In this study, a novel three-dimensional composite scaffold material was successfully fabricated using a combined electrospinning-freeze drying technique. The scaffold incorporates flexible silicon dioxide-strontium oxide (SiO Result: The fabricated scaffolds exhibited an optimal well-ordered porous structure, excellent biocompatibility, and sustained release of therapeutic ions (Si Conclusion: Leveraging the synergistic effects of SiO

Indexed as

Bone tissue engineeringCalvarial repairComposite scaffoldElectrospinningInorganic nanofiberTissue engineering

Identifiers

PMID40620842
PMCPMC12229089

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.