Evidence map›Paper›PMID 40620779›Full record

ArticlePeerJ2025

Structural insights and biomedical potential of biosynthesized silver nanoparticles: antibacterial activity, anti-biofilm and cancer cell inhibition.

Ikram Jemel, Najeh Krayem, Hajer Jlidi, Abir Ben Bacha, Mona Alonazi, Raihane Charguia, Areej Ali Alzahrani, Sami Aifa, Sami Mnif

Abstract read
In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Biosynthesis and Characterization ofNanomaterials (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ikram JemelLaboratory of Molecular and Cellular Screening Processes, Centre of Biotechnology of Sfax, Sfax, Tunisia.
Najeh KrayemLaboratory of Biochemistry and Enzymatic Engineering of Lipases, ENIS, University of Sfax, Sfax, Tunisia.
Hajer JlidiLaboratory of Molecular and Cellular Screening Processes, Centre of Biotechnology of Sfax, Sfax, Tunisia.
Abir Ben BachaDepartment of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
Mona AlonaziDepartment of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
Raihane CharguiaDepartment of Physics, College of Science, Qassim University, Buraydah, Saudi Arabia.
Areej Ali AlzahraniDepartment of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
Sami AifaLaboratory of Molecular and Cellular Screening Processes, Centre of Biotechnology of Sfax, Sfax, Tunisia.
Sami MnifLaboratory of Molecular and Cellular Screening Processes, Centre of Biotechnology of Sfax, Sfax, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The increasing threat of antimicrobial resistance and cancer has driven the search for new therapeutic agents, with plant-based biosynthesis of nanoparticles emerging as a promising approach. Silver nanoparticles (AgNPs) synthesized from plant extracts have gained attention for their potential biomedical applications. Objective: This study aimed to synthesize, characterize, and evaluate the antimicrobial, anti-biofilm, and anticancer properties of AgNPs derived from Methods: AgNPs were synthesized using plant extracts and characterized by X-ray diffraction (XRD), dynamic light scattering (DLS), UV spectroscopy, and Fourier-transform infrared spectroscopy (FTIR). Antibacterial activity was assessed against Gram-negative and Gram-positive bacteria. The anti-biofilm efficacy was tested against Results: XRD confirmed the face-centered cubic (fcc) crystal structure of AgNPs, with peaks at (111), (200), (220), and (311) planes. Crystallite sizes were smaller than their hydrodynamic diameters, suggesting surface modifications affecting DLS measurements. DLS analysis indicated monodisperse size distributions for Tp-AgNPs and Tm-AgNPs, while Pg-AgNPs showed a broader range. The biosynthesized silver AgNPs from different plants exhibit unique physicochemical properties, as evidenced by their distinct UV-vis absorption spectra, and show potential for optical and optoelectronic applications. FTIR spectroscopy analysis confirmed the presence of specific functional groups on the surface of biosynthesized AgNPs, indicating the role of plant extracts as reducing and capping agents, and revealed variations in binding sites and molecular interactions. Among the synthesized nanoparticles, Tp-AgNPs exhibited the highest antibacterial efficacy, particularly against Conclusion: The findings underscored the potent antimicrobial, anti-biofilm, and anticancer properties of Tp-AgNPs and Tm-AgNPs, making them promising candidates for biomedical applications. Further studies are needed to assess their clinical safety and therapeutic potential.

Indexed as

Anti-Bacterial AgentsAntineoplastic AgentsBiofilmsMetal NanoparticlesPlant ExtractsSilverHumansMCF-7 CellsMicrobial Sensitivity TestsPomegranatePseudomonas aeruginosaSpectroscopy, Fourier Transform InfraredStaphylococcus aureusX-Ray DiffractionAnti-Bacterial AgentsAntineoplastic AgentsPlant ExtractsSilverAntibacterial activityAnti-biofilmCancer cell inhibitionNanotechnologyPlant extractsSilver nanoparticles

Identifiers

PMID40620779
PMCPMC12226986

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.