ArticlePeerJ2025
Serum miR-15a-5p may predict recurrence of atrial fibrillation after catheter ablation: a single center retrospective study.
Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- MicroRNAs in Cardiovascular Diseases: Molecular Networks of Cellular Homeostasis, Inflammation, and Pathological Remodeling.International journal of molecular sciences · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: There is still a lack of an easily obtainable, sensitive, and specific biomarker for predicting the recurrence of atrial fibrillation (AF) after radiofrequency catheter ablation (RFCA). In the present study, we aimed to investigate the predictive value of serum miR-15a-5p as a biomarker of recurrence in AF patients undergoing RFCA. Methods: Forty-three consecutive AF patients indicated for RFCA and 20 non-AF subjects were enrolled. The levels of serum miR-15a-5p and PICP, PIIINP, MMP-9, and sST2 were detected. Then, linear regression analysis, binary logistic regression analysis, and receiver operating characteristic (ROC) analysis were used to investigate the correlation between the expression level of serum miR-15a-5p and the degree of myocardial fibrosis and assess the value of serum miR-15a-5p for predicting postoperative recurrence of AF. Results: There was a significant difference in age, CK-MB, uric acid (UA), left atrial diameter (LAD), history of coronary heart disease (CAD), and left ventricular ejection fraction (LVEF) between the AF group and the control group ( Conclusions: The high expression of serum miR-15a-5p in AF patients was related to the degree of myocardial fibrosis and the recurrence of AF after RFCA, which indicated that serum miR-15a-5p could be used as a serum biomarker for predicting AF recurrence after RFCA.
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