Evidence map›Paper›PMID 40620767›Full record

Trial reportPeerJ2025

Effects of glycopyrronium bromide versus anisodamine hydrobromide in preventing nausea and vomiting and relieving spasm after ERCP: a randomized controlled trial.

Qingjing Ma, Dina Sun, Yan Rao, Yi Yang, Jie Liu, Chunmu Miao, Guangyou Duan, Guizhen Chen, Jie Chen

Abstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qingjing Ma *Department of Anesthesiology, The Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing, China.
Dina Sun *Department of Gynecology and Obstetrics, The Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing, China.
Yan RaoDepartment of Anesthesiology, The Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing, China.
Yi YangDepartment of Anesthesiology, The Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing, China.
Jie LiuDepartment of Anesthesiology, The Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing, China.
Chunmu MiaoDepartment of Hepatobiliary Surgery, The Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing, China.
Guangyou DuanDepartment of Anesthesiology, The Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing, China.
Guizhen ChenDepartment of Anesthesiology, The Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing, China.
Jie ChenDepartment of Anesthesiology, The Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Postoperative nausea and vomiting (PONV) frequently occur in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) under general anesthesia. Glycopyrronium bromide, an anticholinergic medication, is believed to not only relieve gastrointestinal spasms but also effectively prevent PONV. Objective: To compare the incidence of nausea and vomiting and the effect of relieving spasm between patients administered glycopyrronium bromide and those given anisodamine hydrobromide following endoscopic retrograde cholangiopancreatography (ERCP). Design: This is a monocentric prospective study. Methods: Patients eligible for ERCP were randomly assigned to two groups. One group received 0.2 mg glycopyrronium bromide (Group G) intravenously, while the other group received 10 mg anisodamine hydrobromide (Group A) intramuscularly for anesthesia induction. The study assessed duodenal motility during ERCP and the incidence of PONV within 24 hours. Results: The study included 130 patients. Nausea and vomiting within 24 hours post-surgery occurred in nine patients (13.8%) in Group G and 19 patients (29.2%) in Group A, with statistical significance (relative risk (RR), 0.47; 95% confidence interval (CI) [0.02-0.29]; Conclusion: For patients undergoing ERCP under general anesthesia, a subcutaneous injection of 0.2 mg glycopyrronium bromide significantly reduces PONV and provides similar anti-spasmodic effects to 10 mg intramuscular anisodamine hydrobromide.

Indexed as

AntiemeticsCholangiopancreatography, Endoscopic RetrogradeGlycopyrrolateMuscarinic AntagonistsPostoperative Nausea and VomitingSolanaceous AlkaloidsSpasmAdultAgedFemaleHumansMaleMiddle AgedProspective StudiesanisodamineAntiemeticsGlycopyrrolateMuscarinic AntagonistsSolanaceous AlkaloidsERCPGeneral anesthesiaGlycopyrronium bromideNausea and vomitingPONV

Identifiers

PMID40620767
PMCPMC12226988

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.