Evidence map›Paper›PMID 40620711›Full record

ReviewNPJ acoustics2025

Sonobiopsy for sensitive and spatially targeted molecular diagnosis through integrating ultrasound with liquid biopsy.

Jinyun Yuan, Hong Chen

Abstract readReview
In one paragraph

Review in NPJ acoustics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jinyun YuanDepartment of Neurosurgery, Washington University School of Medicine, St. Louis, MO USA.
Hong ChenDepartment of Neurosurgery, Washington University School of Medicine, St. Louis, MO USA.

Funding

Ultrasound-induced artificial hibernation: Mimicking natural hibernation to enhance human healthDP1DK143574 · NIDDK · WASHINGTON UNIVERSITY · PI Hong Chen · 2024 to 2026
$5.4M
Image-guided focused ultrasound-mediated intranasal brain drug delivery technique (FUSIN)R01EB027223 · NIBIB · WASHINGTON UNIVERSITY · PI Hong Chen · 2019 to 2026
$4.3M
Focused ultrasound-enabled brain tumor liquid biopsy (FUS-LBx) supplementR01EB030102 · NIBIB · WASHINGTON UNIVERSITY · PI Hong Chen · 2020 to 2026
$4.3M
Sonobiopsy for Noninvasive Genetic Evaluation of Glioblastoma PatientsR01CA276174 · NCI · WASHINGTON UNIVERSITY · PI Hong Chen, Eric CLAUDE Leuthardt · 2023 to 2026
$2.6M
NCI NIH HHS R01 CA276174NIBIB NIH HHS R01 EB027223NIBIB NIH HHS R01 EB030102NIDDK NIH HHS DP1 DK143574
6 · The paper itself

Abstract

Sonobiopsy uses focused ultrasound to enrich circulating biomarkers from ultrasound-targeted disease regions, enabling sensitive and spatially targeted molecular diagnosis through liquid biopsy. Since the concept of integrating ultrasound with liquid biopsy was introduced in 2009, the field has advanced to incorporate various ultrasound modalities for applications across a range of diseases. To drive clinical translation of sonobiopsy, it is essential to optimize focused ultrasound techniques, enhance biomarker analysis, and elucidate underlying mechanisms.

Indexed as

Biological physicsUltrasound

Identifiers

PMID40620711
PMCPMC12226346

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.