Evidence map›Paper›PMID 40620656›Full record

ArticleCentral-European journal of immunology2025

Aberrant glucose metabolism drives dysfunction of CD4

Lu Jin, Meng Ding, Shaoxin Cui, Lin Yang, Jinwen Zhao, Jingjing He, Xiaoping Wang, Fei Chang, Xue Liu, Qun Wang and 3 more

Abstract read
In one paragraph

Article in Central-European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Metabolic regulation of Th17/Treg balance.Central-European journal of immunology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lu Jin *The Second Hospital of Hebei Medical University, China.
Meng Ding *The Second Hospital of Hebei Medical University, China.
Shaoxin CuiThe Second Hospital of Hebei Medical University, China.
Lin YangThe Second Hospital of Hebei Medical University, China.
Jinwen ZhaoThe Second Hospital of Hebei Medical University, China.
Jingjing HeThe Second Hospital of Hebei Medical University, China.
Xiaoping WangThe Second Hospital of Hebei Medical University, China.
Fei ChangThe Second Hospital of Hebei Medical University, China.
Xue LiuThe Second Hospital of Hebei Medical University, China.
Qun WangThe Second Hospital of Hebei Medical University, China.
Hongtao JinThe Second Hospital of Hebei Medical University, China.
Jun MaHebei Research Center for Stem Cell Medical Transitional Engineering, China.
Aijing LiuThe Second Hospital of Hebei Medical University, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: T cell immuno-metabolic regulation plays a key role in the development of systemic lupus erythematosus (SLE). This study aimed to analyze the role of CD4 Material and methods: Clinical data and blood samples were collected from 20 untreated SLE patients and healthy controls (HCs) matched for age, sex, and body mass index. After being isolated by magnetic sorting and cultured with anti-CD3/CD28 for 72 h, CD4 Results: Compared to HCs, SLE-CD4 Conclusions: CD4

Indexed as

CD4+ T cellscytokinesglucose metabolismSLEDAI-2Ksystemic lupus erythematosus

Identifiers

PMID40620656
PMCPMC12224248

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.