ArticleJournal of pain research2025
Intravenous Streptozotocin Induces Variants in Painful Diabetic Peripheral Neuropathy in Female Mice.
Article in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- TLR4 deletion reduces small fiber sensory abnormalities and nerve degeneration in diabetic male mice.Neuroscience · 2025Article
Corrections and comments
- Update of
Authors and funding
5 authors.
Funding
Abstract
Purpose: At least half of the 34 million diabetic patients in the US develop painful diabetic peripheral neuropathy (DPN). Recent evidence suggests that there are sex differences in the prevalence and mechanisms underlying pathological pain states. However, due to technical limitations in murine models, there is a dearth of the use of females in diabetic neuropathy research. There is a need to develop a reproducible model to induce painful DPN in both sexes. The predominately used model employs streptozotocin (STZ) administration via intraperitoneal injections. This strategy consistently induces diabetic pathology in males, but not females. We set out to enhance a current murine DPN model by identifying a method for inducing diabetic pathologies in male and female mice and tracking the development of painful neuropathy. Methods: Painful DPN was induced in both male and female mice through five daily intravenous injections of STZ. Metrics of diabetic pathology and pain behaviors were assessed across the development of painful DPN. To investigate neuronal sensitivity, calcium imaging assessing dorsal root ganglia neurons was performed. Results: We found that after intravenous administration of STZ, both male and female mice exhibited elevated blood glucose levels, impaired glucose tolerance, and increased mechanical and thermal hypersensitivity. Interestingly, we observed a subset of STZ-insensitive animals that displayed comparable elevated glucose levels to the STZ-sensitive animals. Calcium imaging was performed to investigate neuronal sensitivity and we found that both male and female mice with diabetic pathology had a lower latency to peak capsaicin-induced response compared to their control counterparts. Conclusion: Our findings demonstrate that intravenous administration of STZ can induce comparable diabetic neuropathy in male and female mice and opens the door for future preclinical studies on diabetic neuropathy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.