Evidence map›Paper›PMID 40620472›Full record

ArticleBrain communications2025

Decreased diffusion tensor image analysis along the perivascular space index is related with clinical classification in essential tremor.

Yan Qin, Runcheng He, Xun Zhou, Mingqiang Li, Na Tan, Lanqing Liu, Yuwen Zhao, Zhenhua Liu, Qian Xu, Jifeng Guo and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yan QinDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Runcheng HeDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Xun ZhouDepartment of Geriatric Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Mingqiang LiDepartment of Neurology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China.
Na TanDepartment of Ultrasound Medicine, Shenzhen Yan Tian District People's Hospital (Group), Shenzhen, Guangdong 518083, China.
Lanqing LiuDepartment of Geriatric Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Yuwen ZhaoNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Zhenhua LiuNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Qian XuNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Jifeng GuoNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.ORCID https://orcid.org/0000-0002-3658-3928
Xinxiang YanNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Beisha TangNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.ORCID https://orcid.org/0000-0003-2120-1576
Dongcui WangDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.ORCID https://orcid.org/0000-0002-4435-2214
Qiying SunNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The glymphatic dysfunction involved in various neurodegenerative diseases. However, the relationship between glymphatic activity and essential tremor (ET) has not been fully elucidated. Our study explored the impact of glymphatic function on ET and its clinical classification. Participants comprised 37 pure ET, 38 ET-plus and 50 normal controls. Glymphatic function was evaluated via the diffusion tensor image analysis along the perivascular space (DTI-ALPS) index. Statistical comparisons of DTI-ALPS index among patients with pure ET, those with ET-plus and normal controls were conducted using general linear model analysis. Age, gender and disease duration were included as confounding variable. To confirm the relation between the DTI-ALPS index and the clinical characteristics of pure ET and ET-plus, we conducted partial Spearman rank correlation analyses while controlling for age and disease duration. The DTI-ALPS index in ET-plus patients was significantly lower than that in normal controls (

Indexed as

clinical classificationdiffusion tensor imaging along the perivascular space (DTI-ALPS) indexessential tremorglymphatic function

Identifiers

PMID40620472
PMCPMC12225669

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.