ArticleInternational journal of women's dermatology2025
The effects and safety of sequential high concentration glycolic acid and trichloroacetic acid chemical peels in skin photo-type IV-VI, a retrospective cross-sectional monocentric review.
Article in International journal of women's dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Melasma is a common chronic form of cutaneous hyperpigmentation, particularly prevalent in individuals with Fitzpatrick skin phototypes IV-VI, and it predominantly affects the facial areas of women. The patients with melasma often experience a significant reduction in quality of life. Treating melasma is challenging, as no single gold-standard therapy exists, and higher concentrations (>30%) of trichloroacetic acid peels have been inadequately studied in darker skin phototypes due to the potential complications. Purpose: To evaluate the effectiveness and safety of a sequential chemical peel protocol for treating melasma in African patients. Objective: To describe the clinical effects and safety parameters of African patients treated sequentially with glycolic acid and trichoroacetic acid chemical peels. Methods: This retrospective, cross-sectional, single-center review analyzed medical records of patients with melasma who received a sequential peeling protocol. Data collected included patient demographics, adverse effects, visual analogue scale (VAS) pain scores, and modified melasma area and severity index scores at baseline, 12 weeks, and 24 weeks. Descriptive statistics, including interquartile range, analysis of variance, Pearson's correlation, and logistic regression, were applied to analyze treatment outcomes and tolerability. Results: Records of patients with melasma were reviewed, with the majority being female ( Limitations: Owing to the single-center setting as well as the retrospective nature of the study, the results of this study necessitate further prospective randomized controlled studies to validate these findings. Conclusion: Despite recurrences, this study found that a sequential chemical peel protocol using glycolic acid and trichloroacetic acid was effective in reducing melasma severity without causing scarring.
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