Articlenpj biomedical innovations2025
Biocompatibility of decellularized spinach leaves.
Article in npj biomedical innovations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Growing Relevance of Decellularized Plant Material as Functional Scaffolds in Tissue Engineering and Cultured Meat: A Scoping Review on Recent Advances, Challenges, and Future Directions.Annals of biomedical engineering · 2026Review
- Mechanical Properties and Microstructure of Decellularized Brown Seaweed Scaffold for Tissue Engineering.Bioengineering (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Previously, we demonstrated the potential of decellularized spinach leaves to act as prevascularized scaffolds for tissue engineering. In this follow-up study, we aim to further probe this technology's efficacy through investigation of leaf scaffold biocompatibility. Decellularization protocols were modified to limit possible toxicity by lowering the time and concentration of detergents used. Decellularized leaves that were processed with this modified technique were found to have limited effects on cell viability in a leaching assay. To evaluate biocompatibility, decellularized leaves were implanted subcutaneously in Sprague Dawley rats. Leaves maintained a limited immunological response 4 weeks post-implantation. A separate group of decellularized leaves were pre-functionalized with an RGD-dopamine peptide and subsequently implanted. These functionalized leaf implants integrated into the host tissue within 1-week, with visible rat collagen deposition found within the leaf scaffold. These findings further demonstrate the suitability of leaves as scaffolding for tissue engineering and suggest exploration for clinical use.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.