ArticleSAGE open medicine2025
Sodium-glucose cotransporter-1 inhibition and depression: A Mendelian randomization study.
Article in SAGE open medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Objective: The present study aims to determine the causal association between sodium-glucose cotransporter inhibitors and depression, as previous observational studies have concluded a potential link between sodium-glucose cotransporter 1/2 inhibition and depression. Methods: A total of 16 instrumental variables mimicking sodium-glucose cotransporter-1 inhibition and 6 instrumental variables mimicking sodium-glucose cotransporter-2 inhibition were selected for the study. Depression data from the Psychiatric Genomics Consortium and the UK Biobank ( Results: Our results indicated that genetically predicted sodium-glucose cotransporter-1 inhibition was negatively related with depression risk (OR Conclusions: The findings of this Mendelian randomization study indicate that sodium-glucose cotransporter-1 inhibition may decrease the risk of depression in the European population. Future studies must be done to clarify the mechanisms that underlie the causal relationship. Our study provides clear evidence of the potential benefits of sodium-glucose cotransporter-1 inhibition in depression.
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