Evidence map›Paper›PMID 40620301›Full record

ArticlePrzeglad gastroenterologiczny2025

Evaluation of glutamate dehydrogenase (GLDH) as a diagnostic and prognostic marker in drug-induced liver injury.

Omkolsoum Alhaddad, Maha Elsabaawy, Amany Salah, Olfat Hendy, Dalia Elsabaawy, Mohamed Mazaly, Aliaa Sabry

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In one paragraph

Article in Przeglad gastroenterologiczny, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Omkolsoum AlhaddadHepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Shebin El Kom, Egypt.
Maha ElsabaawyHepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Shebin El Kom, Egypt.
Amany SalahHepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Shebin El Kom, Egypt.
Olfat HendyClinical Pathology Department, National Liver Institute, Menoufia University, Shebin El Kom, Egypt.
Dalia ElsabaawyClinical Pharmacy Department, Faculty of Pharmacy, Menoufia University, Shebin El Kom, Egypt.
Mohamed MazalyHepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Shebin El Kom, Egypt.
Aliaa SabryHepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Shebin El Kom, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Drug-induced liver injury (DILI) is a significant clinical event, associated with notable morbidity and mortality. The paucity of DILI diagnostic and/or prognostic biomarkers still represents an unmet need. Aim: We aimed to evaluate the role of glutamate dehydrogenase (GLDH) as a diagnostic and prognostic marker in patients with DILI. Material and methods: A case-control study was conducted on 40 acute DILI patients and 40 acute viral hepatitis patients, in addition to a healthy control group (20). Clinical and laboratory characteristics were evaluated including ELISA assay of GLDH, along with RUCAM score and liver biopsy whenever feasible. All cases were followed up for 6 months. Results: Diclofenac was the most incriminated drug in DILI (40%). GLDH was higher in the DILI than control and acute viral hepatitis patients (18.5 ±10.4, 0.89 ±0.6, 1.5 ±1.2 U/l) respectively ( Conclusions: GLDH is a highly specific, simple, real-time, and inexpensive diagnostic and prognostic marker of DILI and shows potential to address this unmet need.

Indexed as

diagnosticdrug-induced liver injuryglutamate dehydrogenasemarkerprognostic

Identifiers

PMID40620301
PMCPMC12224239

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