Evidence map›Paper›PMID 40620297›Full record

ArticleNpj biological timing and sleep2025

The molecular clock drives motivated locomotion and time-of-day-dependent firing patterns in mouse dopaminergic neurons.

Ananya Swaroop, Jodi R Paul, Laura J McMeekin, Ashley M Barnett, Alana M Colafrancesco, Drèson L Russell, Camille M Smith, Micah S Simmons, Laura A Volpicelli-Daley, Rita M Cowell and 1 more

Abstract read
In one paragraph

Article in Npj biological timing and sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ananya Swaroop *Department of Psychiatry and Behavioral Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL USA.
Jodi R Paul *Department of Psychiatry and Behavioral Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL USA.
Laura J McMeekinDepartment of Neuroscience, Southern Research, Birmingham, AL USA.
Ashley M BarnettDepartment of Psychiatry and Behavioral Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL USA.
Alana M ColafrancescoDepartment of Psychiatry and Behavioral Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL USA.
Drèson L RussellDepartment of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL USA.
Camille M SmithDepartment of Psychiatry and Behavioral Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL USA.
Micah S SimmonsDepartment of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL USA.
Laura A Volpicelli-DaleyDepartment of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL USA.
Rita M CowellDepartment of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL USA.
Karen L GambleDepartment of Psychiatry and Behavioral Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL USA.

Funding

Interdisciplinary Training in Pathobiology and Rehabilitation Medicine.T32HD071866 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JAMES RIMMER, Anna E. Thalacker-Mercer · 2012 to 2026
$4.8M
Glial Involvement in REDOX Homeostasis in the Substantia NigraR01NS124037 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI COWELL, RITA MARIE · 2021 to 2025
$2.8M
The Nigral Molecular Clock and Vulnerability to NeurodegenerationR01NS108713 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI COWELL, RITA MARIE, GAMBLE, KAREN L · 2018 to 2022
$2.3M
UAB Training Program In NeuroscienceT32NS095775 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Erik D Roberson · 2017 to 2026
$1.6M
NICHD NIH HHS T32 HD071866NINDS NIH HHS R01 NS108713NINDS NIH HHS R01 NS124037NINDS NIH HHS T32 NS095775
6 · The paper itself

Abstract

Though circadian locomotor rhythms are primarily driven by the suprachiasmatic nucleus, voluntary motor behavior also requires dopaminergic neuron (DAN) activity. However, it is unknown whether DAN molecular and electrophysiological properties and rhythmic motor behaviors are dependent on a molecular clock. Here, we show substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) DANs rhythmically express clock genes, and conditional deletion of

Indexed as

Circadian rhythmsCircadian rhythms and sleepElectrophysiology

Identifiers

PMID40620297
PMCPMC12226335

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.