Evidence map›Paper›PMID 40620236›Full record

ArticleStroke2025

Left Atrial Diverticula Detected on Cardiac CT in Patients With Acute Ischemic Stroke: A Substudy of Mind the Heart.

Shan Sui Nio, Leon A Rinkel, Olivia N Cramer, Z Beyda Özata, Chiel F P Beemsterboer, Valeria Guglielmi, Berto J Bouma, S Matthijs Boekholdt, Nick H J Lobé, Ludo F M Beenen and 7 more

Abstract read
In one paragraph

Article in Stroke, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Shan Sui NioDepartments of Neurology (S.S.N., L.A.R., O.N.C., Z.B.O., C.F.P.B., V.G., Y.B.W.E.M.R., J.M.C.) Amsterdam UMC Location University of Amsterdam, the Netherlands.ORCID 0000-0003-3401-7014
Leon A RinkelDepartments of Neurology (S.S.N., L.A.R., O.N.C., Z.B.O., C.F.P.B., V.G., Y.B.W.E.M.R., J.M.C.) Amsterdam UMC Location University of Amsterdam, the Netherlands.ORCID 0000-0002-0291-8515
Olivia N CramerDepartments of Neurology (S.S.N., L.A.R., O.N.C., Z.B.O., C.F.P.B., V.G., Y.B.W.E.M.R., J.M.C.) Amsterdam UMC Location University of Amsterdam, the Netherlands.ORCID 0009-0006-4778-6022
Z Beyda ÖzataDepartments of Neurology (S.S.N., L.A.R., O.N.C., Z.B.O., C.F.P.B., V.G., Y.B.W.E.M.R., J.M.C.) Amsterdam UMC Location University of Amsterdam, the Netherlands.ORCID 0009-0009-6930-1040
Chiel F P BeemsterboerDepartments of Neurology (S.S.N., L.A.R., O.N.C., Z.B.O., C.F.P.B., V.G., Y.B.W.E.M.R., J.M.C.) Amsterdam UMC Location University of Amsterdam, the Netherlands.ORCID 0000-0003-1665-2911
Valeria GuglielmiDepartments of Neurology (S.S.N., L.A.R., O.N.C., Z.B.O., C.F.P.B., V.G., Y.B.W.E.M.R., J.M.C.) Amsterdam UMC Location University of Amsterdam, the Netherlands.ORCID 0000-0002-5531-4766
Berto J BoumaDepartments of Cardiology (B.J.B., S.M.B.) Amsterdam UMC Location University of Amsterdam, the Netherlands.ORCID 0000-0002-1433-9692
S Matthijs BoekholdtDepartments of Cardiology (B.J.B., S.M.B.) Amsterdam UMC Location University of Amsterdam, the Netherlands.ORCID 0000-0002-0861-0765
Nick H J LobéDepartments of Radiology and Nuclear Medicine (N.H.J.L., L.F.M.B., N.A.T., H.A.M., C.B.L.M.M., A.v.R.) Amsterdam UMC Location University of Amsterdam, the Netherlands.ORCID 0000-0002-7991-5021
Ludo F M BeenenDepartments of Radiology and Nuclear Medicine (N.H.J.L., L.F.M.B., N.A.T., H.A.M., C.B.L.M.M., A.v.R.) Amsterdam UMC Location University of Amsterdam, the Netherlands.ORCID 0000-0001-9204-1026
Nerea Arrarte TerrerosDepartments of Radiology and Nuclear Medicine (N.H.J.L., L.F.M.B., N.A.T., H.A.M., C.B.L.M.M., A.v.R.) Amsterdam UMC Location University of Amsterdam, the Netherlands.ORCID 0000-0002-9912-7508
Henk A MarqueringDepartments of Radiology and Nuclear Medicine (N.H.J.L., L.F.M.B., N.A.T., H.A.M., C.B.L.M.M., A.v.R.) Amsterdam UMC Location University of Amsterdam, the Netherlands.ORCID 0000-0002-1414-6313
Charles B L M MajoieDepartments of Radiology and Nuclear Medicine (N.H.J.L., L.F.M.B., N.A.T., H.A.M., C.B.L.M.M., A.v.R.) Amsterdam UMC Location University of Amsterdam, the Netherlands.ORCID 0000-0002-7600-9568
Yvo B W E M RoosDepartments of Neurology (S.S.N., L.A.R., O.N.C., Z.B.O., C.F.P.B., V.G., Y.B.W.E.M.R., J.M.C.) Amsterdam UMC Location University of Amsterdam, the Netherlands.ORCID 0000-0001-9205-5882
Adrienne van RandenDepartments of Radiology and Nuclear Medicine (N.H.J.L., L.F.M.B., N.A.T., H.A.M., C.B.L.M.M., A.v.R.) Amsterdam UMC Location University of Amsterdam, the Netherlands.ORCID 0009-0003-1753-8755
R Nils Planken *Departments of Radiology, Mayo Clinic, Rochester, MN (R.N.P.).ORCID 0000-0003-3940-4670
Jonathan M Coutinho *Departments of Neurology (S.S.N., L.A.R., O.N.C., Z.B.O., C.F.P.B., V.G., Y.B.W.E.M.R., J.M.C.) Amsterdam UMC Location University of Amsterdam, the Netherlands.ORCID 0000-0002-8284-982X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeft atrial (LA) diverticula are focal outpouchings of the LA wall and may increase ischemic stroke risk. We studied recurrent ischemic stroke in patients with acute ischemic stroke and LA diverticula detected on cardiac computed tomography.

methodsWe used data from a prospective cohort study of patients with acute ischemic stroke undergoing cardiac computed tomography acquired during the acute stroke imaging protocol. Cardiac radiologists systematically assessed the presence and characteristics of LA diverticula, defined as LA wall outpouchings with a length/ostium width ratio >0.5 and length ≥3 mm. We compared recurrent ischemic stroke and functional outcome (modified Rankin Scale) after 2 years between patients with and without LA diverticula, adjusting for age, history of atrial fibrillation and ischemic stroke, and anticoagulation use.

resultsOf 447 included patients (median age 72 [interquartile range (IQR), 62-81], 59% male), 126 (28%) had LA diverticula: median length 6 mm (IQR, 4-8), width 5 mm (IQR, 4-7), and volume 113 mm

conclusionsLA diverticula are a common finding on cardiac computed tomography in patients with acute ischemic stroke, and the risk of recurrent ischemic stroke was increased in these patients, particularly in those with larger diverticula. Atrial diverticula may be a risk factor for recurrent ischemic stroke. REGISTRATION: URL: https://www.onderzoekmetmensen.nl/nl/trial/50352; Unique identifier: NL6413901818.

Indexed as

Brain IschemiaDiverticulumHeart AtriaIschemic StrokeAgedAged, 80 and overAtrial FibrillationFemaleHumansMaleMiddle AgedProspective StudiesRecurrenceTomography, X-Ray Computedanticoagulantsdiverticulumheart atriaischemic strokerisk factorstomography

Identifiers

PMID40620236
PMCPMC12372733

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.