Evidence map›Paper›PMID 40620135›Full record

ArticleBiomacromolecules2025

Human Milk Oligosaccharides Multivalently Presented on Defined Synthetic Neo-Glycoproteins Are Nanomolar Ligands of Tandem-Repeat Galectins.

Jakub Červený, Viktoria Heine, Michaela Hovorková, Petr Brož, Eliška Filipová, Natalia Kulik, Martin Hubálek, Josef Cvačka, Lucie Petrásková, Mirane Florencio-Zabaleta and 8 more

Abstract read
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In one paragraph

Article in Biomacromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jakub ČervenýInstitute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-142 00 Prague 4, Czech Republic.
Viktoria HeineInstitute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-142 00 Prague 4, Czech Republic.
Michaela HovorkováInstitute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-142 00 Prague 4, Czech Republic.
Petr BrožInstitute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-142 00 Prague 4, Czech Republic.
Eliška FilipováInstitute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-142 00 Prague 4, Czech Republic.
Natalia KulikInstitute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-142 00 Prague 4, Czech Republic.
Martin HubálekInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo Náměstí 2, CZ-166 10 Prague 6, Czech Republic.
Josef CvačkaInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo Náměstí 2, CZ-166 10 Prague 6, Czech Republic.ORCID 0000-0002-3590-9009
Lucie PetráskováInstitute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-142 00 Prague 4, Czech Republic.ORCID 0000-0002-7052-5115
Mirane Florencio-ZabaletaCICbioGUNE, Basque Research and Technology Alliance, Parque Científico Tecnológico de Bizkaia Building 801A, E-48160 Derio, Spain.
Sandra DelgadoCICbioGUNE, Basque Research and Technology Alliance, Parque Científico Tecnológico de Bizkaia Building 801A, E-48160 Derio, Spain.
Helena PelantováInstitute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-142 00 Prague 4, Czech Republic.
Zuzana BosákováDepartment of Analytical Chemistry, Faculty of Science, Charles University, Hlavova 8, CZ-128 43 Prague 2, Czech Republic.
Lothar EllingLaboratory for Biomaterials, Institute of Biotechnology and Helmholtz Institute for Biomedical Engineering, RWTH Aachen, Pauwelstr. 20, D-52079 Aachen, Germany.ORCID 0000-0002-3654-0397
Jesus Jiménez-BarberoCICbioGUNE, Basque Research and Technology Alliance, Parque Científico Tecnológico de Bizkaia Building 801A, E-48160 Derio, Spain.ORCID 0000-0001-5421-8513
Ana ArdáCICbioGUNE, Basque Research and Technology Alliance, Parque Científico Tecnológico de Bizkaia Building 801A, E-48160 Derio, Spain.ORCID 0000-0003-3027-7417
Vladimír KřenInstitute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-142 00 Prague 4, Czech Republic.ORCID 0000-0002-1091-4020
Pavla BojarováInstitute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-142 00 Prague 4, Czech Republic.ORCID 0000-0001-7069-0973

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Galectins are small human proteins participating in inflammation processes, immune response, and cancerogenesis. Tandem-repeat galectins comprising Gal-4, Gal-8, and Gal-9 are a vital yet less studied part of the galectin fingerprint in cancer-related processes. The present work studies a library of prepared multivalent neo-glycoproteins decorated with poly-

Indexed as

GalectinsGlycoproteinsMilk, HumanOligosaccharidesBinding SitesHumansLigandsPolysaccharidesTandem Repeat SequencesGalectinsGlycoproteinsLigandsOligosaccharidespoly-N-acetyllactosaminePolysaccharides

Identifiers

PMID40620135
PMCPMC12344693

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.