SynthesisBrain and behavior2025
Multi-Omics Analyses Reveal Relationships Between Gut Microbiota and Frailty.
Synthesis in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- From culture-based to 16S sequencing approaches: oral microbiota changes in aging, frailty, and oral hypofunction - a systematic review.BMC oral health · 2026Pooled it
- TET Enzymes as Epigenetic Integrators in Intestinal Immunity, Inflammation, and Disease.Journal of personalized medicine · 2026Review
- The microbiome-gut-brain axis: a new perspective on the pathogenesis and intervention of frailty.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
introductionObservational studies suggest a strong association between gut microbiota and frailty, but the underlying mechanisms remain unclear. This study aimed to investigate potential causal links and biological pathways linking gut microbiota and frailty.
methodsWe utilized summary-level data of gut microbiota and frailty data from MiBioGen and a genome-wide association meta-analysis. A bidirectional, two-sample Mendelian randomization (MR) analysis was performed to investigate the causal relationship between gut microbiota and frailty. Additional genetic and genomic analyses were conducted to identify common biological pathways.
resultsWe identified eight causal relationships between the gut microbiota composition and frailty. Inverse-variance weighting suggested that genetic liability for the class Betaproteobacteria and genera Allisonella, Bifidobacterium, Clostridium innocuum, and Eubacterium coprostanoligenes was associated with increased frailty risk. In contrast, the class Bacteroidia, genus Eubacterium ruminantium, and the order Bacteroidales were associated with decreased risk. Reverse MR analysis provided no evidence for a causal effect of frailty on gut microbiota composition. In addition, TET2 was identified as a key hub gene associated with frailty, potentially linking gut microbiota to immune dysregulation and aging-related inflammatory pathways.
conclusionsOur findings provide genetic evidence that gut microbiota composition influences frailty risk and highlight TET2 as a potential mechanistic link via immune dysregulation. These results suggest that microbiota-targeted interventions may offer novel strategies for the prevention and management of frailty in older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.