Evidence map›Paper›PMID 40619952›Full record

ArticleBrain and behavior2025

Lavandula angustifolia and Cyperus rotundus Extract Treatments Ameliorate Copper Toxicity in Rats.

Mandana Salari, Faezeh Dahoee, Seyed Jamilaldin Fatemi, Manijeh Dogani

Abstract read
In one paragraph

Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mandana SalariDepartment of Chemistry, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran.
Faezeh DahoeeDepartment of Chemistry, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran.
Seyed Jamilaldin FatemiDepartment of Chemistry, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran.ORCID https://orcid.org/0000-0001-6126-5481
Manijeh DoganiDepartment of Biology, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran.ORCID https://orcid.org/0000-0002-1032-0310

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionProlonged exposure to copper (Cu) induces oxidative stress, which causes neuronal damage and contributes to cognitive decline.

methodsIn this study, we assessed the free radical scavenging potential of Lavandula angustifolia and Cyperus rotundus extracts and compared their ability to counteract the harmful effects of copper in male rats. These plants were selected on the basis of their well-documented antioxidant properties and traditional medicinal uses.

resultsThe results showed that both extracts inhibited over 80% of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals compared to control groups. Additionally, Cu accumulates in the rats' kidneys, liver, and brain, impairing their cognitive performance and liver and kidney function. Exposure to copper also increased malondialdehyde (MDA) and H

conclusionThese results highlight the potential therapeutic benefits of L. angustifolia and C. rotundus extracts in combating copper toxicity.

Indexed as

CopperCyperusLavandulaPlant ExtractsAnimalsAntioxidantsBrainHydrogen PeroxideKidneyLiverMaleMalondialdehydeOxidative StressRatsRats, WistarAntioxidantsCopperHydrogen PeroxideMalondialdehydePlant Extractschelation therapycopper toxicityCyperus rotundusdeferasiroxgene expressionlavenderlearning and memorystress oxidative

Identifiers

PMID40619952
PMCPMC12230346

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.