ArticleTherapeutic delivery2025
Styrene-maleic acid-thymoquinone nanomicelles preparation, and their in vitro and in vivo application in a model of TNBC.
Article in Therapeutic delivery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo develop and characterize a micellar system, SMA-TQ (styrene-maleic acid-thymoquinone), for the potential management of triple-negative breast cancer (TNBC).
methodsSMA synthesis and TQ encapsulation in SMA are described. The loading of TQ in SMA-TQ was established at 20%. The size of SMA-TQ micelle as determined by DLS was in average of 155.2 nm with a polydispersity index of 0.350. In vitro testing was carried out in 4T1 TNBC cell line, and in vivo testing in mice model of TNBC.
resultsIn vitro experiments revealed an added effect of SMA-TQ and doxorubicin (Doxo) at doses of 1-3 mM). In vivo studies showed that the combination of SMA-TQ and Doxo had the least mean tumor growth (509.6%) compared to other treatments.
conclusionObtained results collectively suggest that the combination of SMA-TQ and Doxo has cumulative effects in inhibiting tumor growth, emphasizing the significance of combination therapies to enhance anticancer effectiveness. This work reveals SMA-TQ micellar system as complementary therapeutic option in TNBC.
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