ArticleAnnals of medicine2025
The relationship between homocysteine and new-onset atrial fibrillation in patients with acute myocardial infarction.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
objectiveElevated homocysteine (Hcy) are linked to an augmented risk of cardiovascular disorders. However, relationship between Hcy and in-hospital new-onset atrial fibrillation (NOAF) among patients experiencing acute myocardial infarction (AMI) remains uncertain. This study investigated the association between Hcy and incidence of NOAF in patients with AMI. MATERIALS AND
methodsWe conducted a retrospective cohort study, involving 3,347 patients with AMI. Participants were categorized into tertiles on the basis of Hcy levels during admission, and the outcome was the incidence of NOAF. Logistic regression models were employed to explored the associations between Hcy and NOAF when adjusting for potential confounders. Non-linear relationships were explored using generalized additive models (GAMs) and threshold effect analyses. Stratified analyses were performed to explore the robustness and potential interaction effects of other clinical factors on Hcy-NOAF relationship.
resultsHigher Hcy were consistently linked with a greater likelihood of in-hospital NOAF across all models (OR: 1.03,
conclusionA nonlinear association has been identified between elevated Hcy and the likelihood of in-hospital NOAF among individuals diagnosed with AMI, particularly among those with smaller LAAD measurements.
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