SynthesisBalkan medical journal2025
Effectiveness and Safety of Lattice Radiotherapy in Treating Large Volume Tumors: A Systematic Review and Meta-analysis Based on Single-arm Clinical Studies.
Synthesis in Balkan medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Spatially fractionated radiation therapy for bulky tumors: a systematic review of clinical outcomes and dosimetric challenges.Radiation oncology (London, England) · 2026Pooled it
- Stage IIIB pulmonary sarcomatoid carcinoma treated with spatially fractionated radiotherapy combined with antiangiogenic therapy and sequential chemo-immunotherapy: A case report.Oncology letters · 2026Article
- Dosimetric comparison of pipe-joint versus conventional VMAT for lattice radiotherapy in bulky tumors: a retrospective planning study.Radiation oncology (London, England) · 2026Article
- Exploratory personalized radiobiological modeling of bystander and immune effects to inform SFRT-SBRT scheduling.Medical physics · 2026Article
- Development and validation of an automated evaluation system for lattice radiotherapy using a commercial treatment planning system scripting API.Journal of applied clinical medical physics · 2026Article
- Feasibility, safety, and clinical outcomes analysis of dense-lattice radiation therapy in palliative care for cancer patients´.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- An integrated toolkit for structure generation, optimization, and evaluation in spatially fractionated radiation therapy.Journal of applied clinical medical physics · 2026Article
- Spatially fractionated radiation therapy (SFRT): a scoping review of dosimetric and biological evidence supporting a valley dose-driven translational framework.Radiation oncology (London, England) · 2026Article
- SFRT alleviates symptoms associated with bulky advanced cancer: a retrospective single-center cohort analysis.Frontiers in oncology · 2026Article
- Lattice SFRT in a geriatric patient with an initially inoperable leg bulky sarcoma: case report and literature review.Frontiers in oncology · 2026Article
- Individualized VMAT lattice radiotherapy on a standard flattening-filter linear accelerator for advanced bulky tumors: a retrospective feasibility and early clinical experience.Frontiers in oncology · 2026Article
- Diagnosis-Related Outcome Following Palliative Spatially Fractionated Radiation Therapy (Lattice) of Large Tumors.Cancers · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Lattice radiotherapy (LRT) is a novel spatially fractionated radiotherapy technique specifically designed to treat large tumors more effectively. By alternating high-dose and low-dose regions within the tumor, LRT generates a highly diverse dose distribution. Aims: To review recent literature on LRT to determine its therapeutic efficacy, survival outcomes, and adverse event rates in treating large-volume tumors, thereby strengthening the evidence base for clinical application. Study Design: Systematic review and meta-analysis. Methods: We conducted a meta-analysis of all relevant LRT studies identified in four databases-PubMed, Embase, the Cochrane Library, and Web of Science-from their inception to September 2024. Only full-text articles were considered eligible. This study adhered to the 2020 PRISMA guidelines. Results: The meta-analysis included seven single-arm studies comprising 187 patients. The pooled 3-month complete response rate and partial response rate were 36.67% and 42.49%, respectively, while the three-month progressive disease rate was 7.10%. The tumor volume was reduced by 48.95%. According to survival analysis, the pooled 6-month overall survival rate was 79.27%, with a median response time of 4.25 months. The pooled rates of mild and moderate-to-severe adverse events were 19.40% and 3.37%, respectively. LRT has demonstrated high local control rates and a favorable safety profile in managing large-volume tumors. Conclusion: This is the first systematic meta-analysis examining the efficacy and safety of LRT in treating large-volume tumors. Although further high-quality studies are needed for validation, LRT exhibits encouraging efficiency and safety in patients with large solid tumors exceeding 5 cm in diameter.
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