Trial reportThe Journal of infectious diseases2025
Effectiveness of Long-lasting Insecticide-Impregnated Bed Nets in Controlling Phlebotomus argentipes in Sri Lanka: A Cluster Randomized Controlled Trial.
Trial report in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- High Seropositivity to rK39 and Capture of Leishmania-Infected Sand Flies in Bihar and Jharkhand Emphasize the Need for Post-Elimination Surveillance of Visceral Leishmaniasis in India.The Journal of infectious diseases · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundSri Lanka is endemic for cutaneous leishmaniasis (CL) caused by Leishmania donovani. Long-lasting insecticide-impregnated bed nets (LLINs) have been used for vector control, but their impact on interruption of sand fly bites remains untested in Sri Lanka. This study assessed the efficacy of LLINs as compared with untreated bed nets in reducing vector-human contact and density of Phlebotomus argentipes, the vector of CL in Sri Lanka.
methodsA cluster-randomized trial was conducted with an intervention group (treated nets) and a control group (untreated nets) in CL-endemic sites. Blood was collected at baseline and 6 and 12 months to measure antibodies against a P argentipes salivary marker. Sand flies were collected over 32 months with light traps (Centers for Disease Control and Prevention) and cattle-baited traps. Bioassays assessed LLINs' impact on P argentipes mortality, and new CL cases were monitored postintervention.
resultsPostintervention, antibodies against P argentipes salivary marker significantly decreased by 28.8% at 6 months (P = .00002) and 44.9% at 12 months (P = .00001) in the intervention group as compared with the control group. Although indoor and outdoor monthly captures were significantly reduced in the intervention group vs controls, LLINs' impact on reducing P argentipes density was more pronounced indoors, decreasing by 77.3% after 2 months (P = .00001), 89.3% after 10 months (P = .00001), and 63.1% after 24 months (P = .00003). During follow-up, knockdown and Phlebotomus mortality rates ranged from 100% to 81.54% and 100% to 90.43%, respectively. Six CL cases vs 1 case occurred in the control and intervention groups.
conclusionsLLINs effectively reduced vector exposure and indoor P argentipes density and is a promising intervention for control of CL in Sri Lanka.
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