Evidence map›Paper›PMID 40619677›Full record

ArticleACS applied bio materials2025

pH-Responsive Peptide-Polymer Hydrogel for Biofilm Disruption.

Haritha Asokan-Sheeja, Debdatta Das, Jenny N Nguyen, Jiazhu Xu, Md Tareque Hassan Mukut, Tung H Chau, Joseph A Buonomo, Yi Hong, He Dong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haritha Asokan-SheejaDepartment of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019, United States.
Debdatta DasDepartment of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019, United States.
Jenny N NguyenDepartment of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019, United States.
Jiazhu XuDepartment of Bioengineering, The University of Texas at Arlington, Arlington, Texas 76019, United States.
Md Tareque Hassan MukutDepartment of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019, United States.
Tung H ChauDepartment of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019, United States.
Joseph A BuonomoDepartment of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019, United States.ORCID 0000-0002-9618-0215
Yi HongDepartment of Bioengineering, The University of Texas at Arlington, Arlington, Texas 76019, United States.ORCID 0000-0002-5846-2596
He DongDepartment of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019, United States.ORCID 0000-0002-8494-0475

Funding

Bioactive adhesive material for early vaginal wall detachment in pelvic organ prolapseR01HD097330 · NICHD · UNIVERSITY OF TEXAS ARLINGTON · PI HONG, YI · 2019 to 2023
$1.6M
Biodegradable elastic patches for congenital diaphragmatic hernia treatmentR21HD107324 · NICHD · UNIVERSITY OF TEXAS ARLINGTON · PI HONG, YI, WANG, AIJUN · 2022 to 2023
$441k
NICHD NIH HHS R01 HD097330NICHD NIH HHS R21 HD107324
6 · The paper itself

Abstract

Biofilm formation presents a significant challenge in chronic infections as it enables bacteria to resist conventional antibiotics and thrive in various areas of the body. The treatment is further hurdled by the acidic environment of biofilms due to anaerobic glycolysis of bacteria and the accumulation of acidic byproducts. Therefore, there is a need for the development of antimicrobial materials that can selectively and preferentially eradicate biofilms in the acidic environment. Toward this aim, this study explores the use of acid-responsive double-network peptide-polymer hydrogels encapsulated with antimicrobial peptides to effectively target and disrupt biofilms. The hydrogel consists of two essential components: a self-assembling peptide nanofiber containing a non-natural ionic amino acid, which imparts pH responsiveness in the weakly acidic range, and a 4-arm PEG polymer that forms covalent bonds with the peptide nanofiber, enhancing the hydrogel's mechanical strength. Upon acidification, peptide nanofibers disassemble, causing an increased pore size of the hydrogel and release of encapsulated antimicrobials to the biofilm site. We expect that, by leveraging the unique properties of the double network self-assembled peptide-PEG hydrogels and the pH-triggered release mechanism, this innovative hydrogel approach may offer a more targeted, effective, and safer treatment option against biofilm-associated infections.

Indexed as

Anti-Bacterial AgentsAntimicrobial PeptidesBiocompatible MaterialsBiofilmsHydrogelsPeptidesPolymersEscherichia coliHydrogen-Ion ConcentrationMaterials TestingMicrobial Sensitivity TestsParticle SizePolyethylene GlycolsPseudomonas aeruginosaSurface PropertiesAnti-Bacterial AgentsAntimicrobial PeptidesBiocompatible MaterialsHydrogelsPeptidesPolyethylene GlycolsPolymersantibiofilm activitynon-natural amino acidspeptide−polymer conjugatespH-responsive hydrogelSelf-assembly

Identifiers

PMID40619677
PMCPMC12922601

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.